Burke, A: Active Pharmaceutical Ingredients in Synthesis

1. Auflage 2018
ISBN: 978-3-527-34241-9
Verlag: Wiley-VCH GmbH

Buch, Englisch, 456 Seiten, Format (B × H): 171 mm x 252 mm, Gewicht: 1289 g

Presents the most effective catalytic reactions in use today, with a special focus on process intensification, sustainability, waste reduction, and innovative methods

This book demonstrates the importance of efficient catalytic transformations for producing pharmaceutically active molecules. It presents the key catalytic reactions and the most efficient catalytic processes, including their significant advantages over compared previous methods. It also places a strong emphasis on asymmetric catalytic reactions, process intensification (PI), sustainability and waste mitigation, continuous manufacturing processes as enshrined by continuous flow catalysis, and supported catalysis.

Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development offers chapters covering: Catalysis and Prerequisites for the Modern Pharmaceutial Industry Landscape; Catalytic Process Design - The Industrial Perspective; Hydrogenation, Hydroformylation and Other Reductions; Oxidation; Catalytic Addition Reactions; Catalytic Cross-Coupling Reactions; Catalytic Metathesis Reactions; Catalytic Cycloaddition Reactions: Coming Full-Circle; Catalytic Cyclopropanation Reactions; Catalytic C-H insertion Reactions; Phase Transfer Catalysis; and Biocatalysis.

-Provides the reader with an updated clear view of the current state of the challenging field of catalysis for API production
-Focuses on the application of catalytic methods for the synthesis of known APIs
-Presents every key reaction, including Diels-Alder, CH Insertions, Metal-catalytic coupling-reactions, and many more
-Includes recent patent literature for completeness

Covering a topic of great interest for synthetic chemists and R&D researchers in the pharmaceutical industry, Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development is a must-read for every synthetic chemist working with APIs.

Autoren/Hrsg.

Burke, Anthony J.

Marques, Carolina S.

Turner, Nicholas

Hermann, Gesine

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie
• Naturwissenschaften Chemie Physikalische Chemie Chemische Reaktionen, Katalyse
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Chemische Reaktionstechnik (incl. Katalyse, Elektrolyse)
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie

Inhaltsverzeichnis

Catalysis and Prerequisites for the Modern Pharmaceutial Industry LandscapeCatalytic Process Design - The Industrial PerspectiveHydrogenation, Hydroformylation and Other ReductionsOxidation: Nobel Prize Chemistry CatalysisCatalytic Addition ReactionsCatalytic Cross-Coupling Reactions - Nobel Prize CatalysisCatalytic Metathesis Reactions - Nobel Prize CatalysisCatalytic Cycloaddition Reactions: Coming Full-Circle Catalytic Cyclopropanation ReactionsCatalytic C-H insertion ReactionsPhase Transfer CatalysisBiocatalysis: Nobel Prize Catalysis

Über Autor(innen)

Anthony J. Burke, PhD, is Professor at the University of Evora, and the coordinator of the organic and organometallic research line at the Centro de Química de Evora. Carolina S. Marques, PhD, is working as a PostDoc in the Burke group.Nicholas Turner, PhD, is Professor of Chemical Biology, Director of the Centre of Excellence in Biocatalysis (CoEBio3) and co-Director of SYNBIOCHEM. Gesine J. Hermann, PhD, is a research and business consultant for ChiraTecnics, Portugal.