Iminosugars

From Synthesis to Therapeutic Applications
1. Auflage 2007
ISBN: 978-0-470-03391-3
Verlag: Wiley

Buch, Englisch, 482 Seiten, Format (B × H): 183 mm x 248 mm, Gewicht: 984 g

Iminosugars form undoubtedly the most attractive class of carbohydrate mimics reported so far. In these structures, the substitution of the endocyclic oxygen of sugars by a basic nitrogen atom leads to remarkable biological properties and raises many challenges in organic synthesis. Since the discovery of their biological activity as glycosidase inhibitors in the 1970's, these polyvalent molecules have progressively made their way from the laboratory to the clinic.

The impressive series of discoveries in the field over the past ten years indicates clearly that it is "a boom time" for iminosugar chemistry and biology. The scope of their profile as inhibitors has been extended to a number of enzymes such as phosphorylases, glycosyltransferases or metalloproteinases, and iminosugars now constitute lead compounds for the development of new therapeutic agents for a wide range of diseases including diabetes, viral infections, lysosomal storage disorders and tumor metastasis.

Latest developments, from iminosugar synthesis to their use in clinical studies, are presented in this book, which contains contributions from over fifteen of the major chemists, biochemists and drug developers in this rapidly expanding field. An extensive table correlating the structures of more than 600 iminosugars of therapeutic interest with their biological activities is also included in the book and should prove particularly useful to aid with the design and the discovery of novel bioactive substances.

Iminosugars: From Synthesis to Therapeutic Application provides a unique resource for academic and industrial researchers working in the field of iminosugars and glycomimetics of biological and/or therapeutic interest: organic chemists, medicinal chemists, carbohydrate chemists and medical scientists.

Autoren/Hrsg.

Compain, Philippe

Martin, Olivier R

Fachgebiete

• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Naturwissenschaften Biowissenschaften Kohlenhydrate
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie

Inhaltsverzeichnis

Preface.

List of Contributors.

1 Iminosugars: past, present and future (Philippe Compain and Olivier R. Martin).

2 Naturally occurring iminosugars and related alkaloids: structure, activity and applications (Naoki Asano).

2. Introduction.

References.

3 General strategies for the synthesis of iminosugars and new approaches towards iminosugar libraries. (Barbara la Ferla, Laura Cipolla and Francesco Nicotra)

References.

4 Iminosugar C-glycosides: synthesis and biological activity (Philippe Compain).

References.

5 Imino-C-disaccharides and analogues: synthesis and biological activity (Pierre Vogel, Sandrine Gerber-Lemaire and Lucienne Juillerat-Jeanneret).

References.

6 Isofagomine, noeuromycin and other 1-azasugars, iminosugar related glycosidase inhibitors (Oscar Lopez and Mikael Bols).

References.

7 Iminosugar-based glycosyltransferase inhibitors (Lisa J. Whalen, William A. Greenberg, Michael L. Mitchell and Chi-Huey Wong).

References.

8 Transition state analogue inhibitors of N-Ribosyltransferases (Vern L. Schramm and Peter C. Tyler).

References.

9 Iminosugars as antiviral agents (Pamela A. Norton, Baohua Gu, and Timothy M. Block).

Acknowledgements.

References.

10 Iminosugars as active-site-specific chaperones for the treatment of lysosomal storage disorders. (Jian-Qiang Fan)

References.

11 Iminosugar inhibitors for substrate reduction therapy for the lysosomal glycosphingolipidoses (Terry D. Butters).

Acknowledgements.

References.

12 Iminosugar-based antitumoural agents (Yoshio Nishimura).

References.

13 Medicinal use of iminosugars (Timothy M. Cox, Frances M. Platt and Johannes M. F. G. Aerts).

Acknowledgements.

References.

14 Tables of iminosugars, their biological activities and their potential as therapeutic agents (Philippe Compain, ValÃ(c)rie Desvergnes, Virginie Liautard, Christelle Pillard and Sylvestre Toumieux).

References.

Index.

Über Autor(innen)

Philippe Compain and Olivier R. Martin

CNRS, University of Orléans, France