Domínguez-Bendala | Pancreatic Stem Cells | Buch |

Domínguez-Bendala Pancreatic Stem Cells

2009, 154 Seiten, Gebunden, Book, Format (B × H): 155 mm x 235 mm, Gewicht: 393 g Reihe: Stem Cell Biology and Regenera
ISBN: 978-1-60761-131-8
Verlag: Springer, Berlin

Domínguez-Bendala Pancreatic Stem Cells

From the discovery of Pdx1, the first “master gene” of pancreatic development, to the most recent findings on the role of microRNAs in beta cell homeostasis, the last fifteen years have seen an unprecedented advance in our understanding of the precise development and organization of the many different cell types that make up the pancreas. It is now widely acknowledged that the therapeutic differentiation of stem cells into pancreatic cells is an ambitious endeavor that will not succeed without a thorough understanding of the molecular processes underlying the native development of the organ. This book, aimed at experts and students alike, offers a comprehensive review of the state of the art in both pancreatic development and regeneration. The many strategies to differentiate adult and embryonic stem cells into pancreatic beta cells are also discussed in the context of potential therapeutic interventions for type I diabetes.



Weitere Infos & Material

Table of Contents:

Preface. Importance of the subject in the context of type I diabetes (2-3 pages)

The pancreas (15 pages)

Pancreatic development (50-60 pages)

Pancreatic regeneration (30-40 pages)

Models of regeneration

Stem cells vs. beta cell replication

Stem cell differentiation: general approaches (20-30 pages)

Recapitulation of pancreatic development

Signal-driven strategies

Gene transfer and protein transduction

Physiological variables

Embryonic stem cells and pancreatic differentiation (40 pages)

Adult stem cells and pancreatic differentiation (60 pages)

Bone marrow

Umbilical cord

Ductal and acinar cells

Mesenchymal stem cells and de-differentiation

Transdifferentiation (30 pages)

Remaining challenges and clinical perspectives (20-30 pages)


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