Buch, Englisch, Band 37, 566 Seiten, Paperback, Format (B × H): 160 mm x 240 mm, Gewicht: 926 g
Buch, Englisch, Band 37, 566 Seiten, Paperback, Format (B × H): 160 mm x 240 mm, Gewicht: 926 g
Reihe: Cancer Treatment and Research
ISBN: 978-1-4612-8419-2
Verlag: Springer US
Zielgruppe
Research
Autoren/Hrsg.
Weitere Infos & Material
1. Introduction.- I. Toxin Structure.- 2. Toxin structure.- 3. Structure—activity relationships in diphtheria toxin and Pseudomonas aeruginosa exotoxin A.- II. How Toxins Work.- 4. How protein toxins enter and kill cells.- 5. Mechanism of action of ricin and related toxins on the inactivation of eukaryotic ribosomes.- III. Toxin Selection and Modification.- 6. Toxin selection and modification — Overview.- 7. Toxin selection and modification: Utilization of the A chain of ricin.- 8. Genetic engineering of immunotoxins.- 9. Diphtheria-related peptide hormone gene fusions: A molecular genetic approach to chimeric toxin development.- 10. Immunotoxins containing ricin.- 11. Pseudomonas exotoxin — Immunotoxins.- 12. Immunotoxins containing single chain ribosome-inactivating proteins.- IV. Covalent Linking Agents.- 13. Antibody-toxin conjugation.- 14. Effect of chemical linkage upon the stability and cytotoxic activity of A chain immunotoxins.- V. Antibody Selection.- 15. Immunotoxins: Selection of cell-surface antigens and their corresponding monoclonal antibodies.- VI. Nonantibody Ligands.- 16. Hormone, lectin and toxin-toxin conjugates.- 17. Growth factors and other ligands.- VII. Purification and Chemical Characterization.- 18. Purification and biochemical characterization of immunotoxins.- VIII. Enhancers.- 19. Immunotoxin enhancers.- 20. Enhancement of immunotoxin action: Manipulation of the cellular routing of proteins.- IX. Cytotoxicity.- 21. Methods for quantifying immunotoxin efficacy.- 22. Kinetic analysis of cytotoxicity.- 23. Isolation and analysis of somatic cell mutants resistant to toxin conjugates.- X. Animal Studies.- 24. Immunotoxin therapy: Assessment by animal models.- 25. Prevention of carbohydrate-mediated clearance of ricin-containing immunotoxinsby the liver.- 26. Human immune response to immunotoxins.- XI. Clinical Studies.- 27. Treatment of leukemia patients with T101 ricin A chain immunotoxins.- 28. Clinical studies: Solid tumors.- 29. Immunotoxins for ex vivo bone marrow purging in human bone marrow transplantation.- 30. Conclusion.