Immunotherapy and Biomarkers in Neurodegenerative Disorders

1. Auflage 2016
ISBN: 978-1-4939-3558-1
Verlag: Springer

Buch, Englisch, 289 Seiten, HC runder Rücken kaschiert, Format (B × H): 183 mm x 260 mm, Gewicht: 7099 g

Reihe: Methods in Pharmacology and Toxicology

This practical volume examines a number of topics
that explore the current status of immunotherapy and diagnostic markers for
neurodegenerative disorders. With a focus on Alzheimer’s disease, the first
sections of the book examine immunotherapeutic approaches for the
aforementioned disease as well as for Parkinson’s disease and Huntington’s disease,
amongst others. The last section of the book covers the importance of biomarker
techniques to catch these diseases early enough for the treatments to be most
useful. Written for the Methods in
Pharmacology and Toxicology series, this book contains the kind of detailed
descriptions and implementation advice that will offer a smooth transition into
the lab.

Authoritative and useful, Immunotherapy and Biomarkers in
Neurodegenerative Disorders aims to aid in the continued progress in the
development of novel immune-based drugs and diagnostic tools for these
devastating brain diseases.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Lannfelt, Lars

Ingelsson, Martin

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften Neurobiologie, Verhaltensbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

Part I: Immunotherapy
Against Amyloid-b in
Alzheimer’s Disease



1. Immunotherapy Against Amyloid-ß in Alzheimer’s Disease: An Overview

Niels D. Prins



2. Active Immunization Against the
Amyloid-ß Peptide

Enchi Liu
and J. Michael Ryan



3. Immunotherapy
Against N-Truncated Amyloid-ß Oligomers

Thomas A.
Bayer and Oliver Wirths



4. Immunotherapy
Against Amyloid-ß Protofibrils: Opportunities and Challenges

Lars
Lannfelt



Part II:

Immunotherapy in Other Neurodegenerative Disorders



5. Immunotherapy
Against a-Synuclein Pathology

Elvira
Valera and Eliezer Masliah



6. Extracellular a-Synuclein as a Target for
Immunotherapy

Jun Sung Lee and Seung-Jae Lee



7. Immunotherapy of Parkinson’s Disease

Achim Schneeberger,
Suzanne Hendrix, and Markus Mandler



8. Tau Immunotherapy

Einar M. Sigurdsson



9. Active and Passive Immunotherapy Against Tau: Effects and
Potential Mechanisms

Kiran Yanamandra, Marc
I. Diamond, and David M. Holtzman



10. Immunotherapy on Experimental Models for
Huntington’s Disease