Biochemical Pathways 2e

2. Auflage 2012
ISBN: 978-0-470-14684-2
Verlag: Wiley

Buch, Englisch, 416 Seiten, Format (B × H): 221 mm x 286 mm, Gewicht: 1298 g

The pathways and networks underlying biological function

Now in its second edition, Biochemical Pathways continues to garner praise from students, instructors, and researchers for its clear, full-color illustrations of the pathways and networks that determine biological function.

Biochemical Pathways examines the biochemistry of bacteria, plants, and animals. It offers a quick overview of the metabolic sequences in biochemical pathways, the chemistry and enzymology of conversions, the regulation of turnover, the expression of genes, the immunological interactions, and the metabolic background of health disorders. A standard set of conventions is used in all illustrations, enabling readers to easily gather information and compare the key elements of different biochemical pathways. For both quick and in-depth understanding, the book uses a combination of:

* Illustrations integrating many different features of the reactions and their interrelationships
* Tables listing the important system components and their function
* Text supplementing and expanding on the illustrated facts

In the second edition, the volume has been expanded by 50 percent. Text and figures have undergone a thorough revision and update, reflecting the tremendous progress in biochemical knowledge in recent years. A guide to the relevant biochemical databases facilitates access to the extensive documentation of scientific knowledge.

Biochemical Pathways, Second Edition is recommended for all students and researchers in such fields as biochemistry, molecular biology, medicine, organic chemistry, and pharmacology. The book's illustrated pathways aids the reader in understanding the complex set of biochemical reactions that occur in biological systems.

From the reviews:

". highly recommended for every scientist and student working in biochemistry." -Umwelt & Gesundheit 4/2012 (review in German language)

Autoren/Hrsg.

Michal, Gerhard

Schomburg, Dietmar

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Chemie Organische Chemie Biochemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Biochemie (med.)
• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

Preface to the Second Edition IX

From the Preface to the First Edition X

Contributors XI

1 Introduction and General Aspects 1
Gerhard Michal and Dietmar Schomburg

1.1 Organization of This Book 1

1.2 Carbohydrate Chemistry and Structure 4

1.3 Amino Acid Chemistry and Structure 5

1.4 Lipid Chemistry and Structure 6

1.5 Physico-Chemical Aspects of Biochemical Processess 8

2 The Cell and Its Contents 14
Gerhard Michal and Dietmar Schomburg

2.1 Classification of Living Organisms 14

2.2 Structure of Cells 14

2.3 Protein Structure and Function 18

2.4 Enzymes 21

2.5 Regulation of the Enzyme Activity 24

2.6 Nucleic Acid Structure 26

2.7 Genetic Code and the Flow of Information 30

2.8 Polymeric Carbohydrates 31

2.9 Glycosylated Proteins and Peptides 32

2.10 Lipid Aggregates and Membranes 35

3 Metabolism 37

3.1 Carbohydrate Metabolism and Citrate Cycle 37
Röbbe Wünschiers

3.2 Amino Acids and Derivatives 58
Röbbe Wünschiers

3.3 Tetrapyrroles 82
Martina Jahn and Dieter Jahn

3.4 Lipids and Glycolipids 93
Röbbe Wünschiers

3.5 Steroids and Isoprenoids 107
Röbbe Wünschiers

3.6 Nucleotides and Nucleosides 124
Röbbe Wünschiers

3.7 Cofactors and Vitamins 133
Ida Schomburg

3.8 Nucleic Acid Metabolism in Bacteria 149
Susanne Peifer and Elmar Heinzle

3.9 Nucleic Acid Metabolism in Eukarya 157

Helmut Burtscher

3.10 Special Bacterial Metabolism and Biosynthesis of Antimicrobials 164
Julia Garbe, Annika Steen and Max Schobert

3.11 Electron Transfer Reactions and Oxidative Phosphorylation 183
Martina Jahn and Dieter Jahn

3.12 Photosynthesis 188
Dieter Oesterhelt and Josef Wachtveitl

3.13 Plant Secondary Metabolism 193
Antje Chang

4 Protein Biosynthesis, Modifications and Degradation 210

4.1 Protein Synthesis in Bacteria 210
Martina Jahn and Dieter Jahn

4.2 Protein Biosynthesis in Eukarya 219
Röbbe Wünschiers

4.3 Cell Cycle in Eukarya 232
Stefan Ries

4.4 Posttranslational Modification of Proteins 238
Röbbe Wünschiers

4.5 Protein Folding, Transport / Targeting and Degradation 244
Petra Dersch

5 Viruses 261
Klaus Klumpp

5.1 General Characteristics of Viruses 261

5.2 DNA Viruses 264

5.3 RNA Viruses 267

5.4 Retroviruses 268

6 Transport 272

6.1 Transport Through Membranes 272
Wilhelm Just

6.2 Transport of Lipids in Plasma 279
Horst Klima

6.3 Oxygen Transport by Hemoglobin 282
Gerhard Michal

7 Signal Transduction and Cellular Communication 286
Gerhard Niederfellner

7.1 Intercellular Signal Transmission by Hormones 286

7.2 Nerve Conduction and Synaptic Transmission 294

7.3 Principles of Intracellular Communication 296

7.4 Receptors Coupled to Heterotrimeric G-Proteins 299

7.5 Receptors Acting Through Tyrosine Kinases 311

7.6 Programmed Cell Death (Apoptosis) 319

7.7 Receptors for Steroid and Thyroid Hormones, for Retinoids and Vitamin D 321

7.8 Cyclic GMP Dependent Pathways and Effects of Nitric Oxide (NO) 322

8 Immune System 325
Ernst Peter Rieber

8.1 Components of the Immune System 325

8.2 Generation of a Specific Immune Response 343

8.3 Pathologic Immune responses 352

8.4 Adhesion of Leukocytes 354
Anton Haselbeck

9 Blood Coagulation and Fibrinolysis 357
Peter Müller

9.1 Hemostasis 357

9.2 Initial Reactions 358

9.3 Coagulation Propagation and Control 359

9.4 Platelets (Thrombocytes) 362

9.5 Fibrinolysis 364

10 Biochemical Networks, Bioinformatics and Systems Biology 366
Dietmar Schomburg

10.1 Systems Biology and Networks 366

10.2 Modeling of Metabolic Fluxes 366

10.3 Biochemical Pathways Information Resources 366

Index 374

Über Autor(innen)

Schomburg, Dietmar
DIETMAR SCHOMBURG, PhD, is a Full Professor and Head of the Department of Bioinformatics and Biochemistry at the Technische Universität Carolo-Wilhelmina in Braunschweig. His research interests include protein structure and function, structural biochemistry, bioinformatics, and enzyme information/metabolic networks. Dr. Schomburg has been widely praised for establishing BRENDA, the principal source of enzyme function and property data.

Michal, Gerhard
GERHARD MICHAL, PhD, has retired from research at Boehringer Mannheim GmbH (now Roche Diagnostics). He is internationally acclaimed for developing the "Biochemical Pathways" wall chart. The first edition, which was published some forty years ago, has been continuously updated and is used in many biochemistry laboratories around the world.

GERHARD MICHAL, PhD, has retired from research at Boehringer Mannheim GmbH (now Roche Diagnostics). He is internationally acclaimed for developing the "Biochemical Pathways" wall chart. The first edition, which was published some forty years ago, has been continuously updated and is used in many biochemistry laboratories around the world.

DIETMAR SCHOMBURG, PhD, is a Full Professor and Head of the Department of Bioinformatics and Biochemistry at the Technische Universität Carolo-Wilhelmina in Braunschweig. His research interests include protein structure and function, structural biochemistry, bioinformatics, and enzyme information/metabolic networks. Dr. Schomburg has been widely praised for establishing BRENDA, the principal source of enzyme function and property data.