Multiple Testing Procedures with Applications to Genomics

1. Auflage. Softcover version of original hardcover Auflage 2008
ISBN: 978-1-4419-2379-0
Verlag: Springer

Buch, Englisch, 590 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 931 g

Reihe: Springer Series in Statistics

This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.

Zielgruppe

Research

Autoren/Hrsg.

Laan, Mark J. Van Der

Dudoit, Sandrine

Fachgebiete

• Naturwissenschaften Biowissenschaften Botanik Pflanzenreproduktion, Verbreitung, Genetik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizinische Mathematik & Informatik
• Mathematik | Informatik EDV | Informatik Angewandte Informatik Bioinformatik
• Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
• Interdisziplinäres Wissenschaften Wissenschaften: Forschung und Information Datenanalyse, Datenverarbeitung
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Mathematik | Informatik Mathematik Stochastik Mathematische Statistik
• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Tiergenetik, Reproduktion

Inhaltsverzeichnis

Multiple Hypothesis Testing.- Test Statistics Null Distribution.- Overview of Multiple Testing Procedures.- Single-Step Multiple Testing Procedures for Controlling General Type I Error Rates, ?(Fvn).- Step-Down Multiple Testing Procedures for Controlling the Family-Wise Error Rate.- Augmentation Multiple Testing Procedures for Controlling Generalized Tail Probability Error Rates.- Resampling-Based Empirical Bayes multiple Testing Procedures for Controlling Generalized Tail Probability Error Rates.- Simulation Studies: Assessment of Test Statistics Null Distributions.- Identification of Differentially Expressed and Co-Expressed Genes in High-Throughput Gene Expression Experiments.- Multiple Tests of Association with Biological Annotation Metadata.- HIV-1 Sequence Variation and Viral Replication Capacity.- Genetic Mapping of Complex Human Traits Using Single Nucleotide Polymorphisms: The ObeLinks Project.- Software Implementation.