Overview
- Covers lncRNAs from basic biology to therapeutic application
- Provides in-depth analysis of the role that lncRNA play in inflammation
- Discusses pros and cons of current approaches and speculates on the future of the field
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1363)
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Table of contents (10 chapters)
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Front Matter
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Overview
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Front Matter
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Basics of Long Noncoding RNA Classifications and Functions
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Front Matter
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Long Noncoding RNA and Inflammation
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Front Matter
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Long Noncoding RNAs as Therapeutic Targets
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Front Matter
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Challenges and Future Directions
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Front Matter
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Back Matter
Keywords
About this book
Editors and Affiliations
About the editor
Susan Carpenter is an assistant professor of Molecular, Cell and Developmental Biology at UC Santa Cruz.
Susan’s lab focuses on understanding the complex molecular mechanisms that control the body’s essential protection against infection. Any perturbation to these mechanisms can have devastating consequences and result in inflammatory conditions such as rheumatoid arthritis. Recent evidence shows that a group of RNA molecules known as long noncoding RNA or lncRNA plays important roles in diverse biological functions, including the inflammatory response. They are studying lncRNAs to gain an understanding of their function within the immune system, which could lead to insight into human disease and perhaps novel targets for therapeutic intervention for inflammatory conditions
Susan earned her PhD in Biochemistry from Trinity College in Dublin, Ireland, studying novel proteins important within innate immune signaling pathways,working under the supervision of Professor Luke O’Neill. Her post-doctoral research with Prof. Kate Fitzgerald at UMASS medical school continued in this area, and there she focused her attention on the role of lncRNA in inflammatory signaling pathways. Since her research bridges the fields of immunology and RNA biology, she also took the opportunity to work at UCSF in the laboratory of Dr. Michael McManus, who is a pioneer in high throughput technologies. There she worked on developing high throughput genomic approaches to study lncRNAs important for human innate immune signaling in host defense mechanisms.
Bibliographic Information
Book Title: Long Noncoding RNA
Book Subtitle: Mechanistic Insights and Roles in Inflammation
Editors: Susan Carpenter
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-030-92034-0
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022
Hardcover ISBN: 978-3-030-92033-3Published: 28 February 2022
Softcover ISBN: 978-3-030-92036-4Published: 01 March 2023
eBook ISBN: 978-3-030-92034-0Published: 27 February 2022
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: IX, 189
Number of Illustrations: 1 b/w illustrations, 11 illustrations in colour
Topics: Systems Biology, Gene Expression, Gene Function, Immunology