Overview
- Discusses modern vaccine approaches aiming to cope with highly variable pathogens
- Provides the reader with a better understanding of antigen design, immunodominance, analysis of antibody responses and vaccine formulations
- An invaluable source of information for the fight against emerging viruses
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 428)
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Table of contents (6 chapters)
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Front Matter
Keywords
About this book
Vaccines against antigenically stable pathogens, or pathogens that only exist in a limited number of serotypes, have been very successful in the past and have drastically decreased the incidence and lethality of many diseases. However, when it comes to highly variable pathogens or viruses that exist in multiple serotypes, the traditional methods for vaccine development have reached their limits.
This volume highlights the development of vaccines against such challenging pathogens. Novel approaches for immunogen design, including structure-guided vaccine development and vaccines targeting glycans, as well as adjuvants and animal models used for testing possible vaccine candidates are outlined and discussed in detail. Given its scope, the book will appeal to scientists in the fields of infectious diseases, microbiology and medicine.
Editors and Affiliations
About the editors
Lars Hangartner is a molecular biologist and immunologist whose research focuses on the humoral response against variable pathogens, such as influenza A virus and HIV. Moreover, he has performed basic studies on measles virus and lymphocytic choriomeningitis virus. He is currently an associate professor at the Scripps Research Institute in La Jolla, California, and his present research investigates Fc/FcγR interactions as well as epitope mapping of polyclonal antibody response in the context of HIV vaccine development.
Dennis R. Burton, Ph.D.
Dennis Burton is the Chair and Professor in the Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA and James and Jessie Minor Chair in Immunology. He is the Scientific Director of the IAVI Neutralizing Antibody Center, Director of The Consortium for HIV/AIDS Vaccine Development (CHAVD) at Scripps, and a member of the Ragon Institute of MGH, MIT and Harvard, Boston, USA. His research is focused on infectious disease, in particular the interplay of antibodies and highly mutable viruses, notably HIV. He is interested in the potential of broadly neutralizing antibodies to inform vaccine design.
Bibliographic Information
Book Title: Vaccination Strategies Against Highly Variable Pathogens
Editors: Lars Hangartner, Dennis R. Burton
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-030-58004-9
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2020
Hardcover ISBN: 978-3-030-58003-2Published: 02 September 2020
Softcover ISBN: 978-3-030-58006-3Published: 02 September 2021
eBook ISBN: 978-3-030-58004-9Published: 01 September 2020
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: VII, 180
Number of Illustrations: 1 b/w illustrations, 15 illustrations in colour
Topics: Vaccine, Infectious Diseases, Virology, Immunology, Human Physiology