Reddy / Yang / Andersen Physiologically Based Pharmacokinetic Modeling

Science and Applications
1. Auflage 2005
ISBN: 978-0-471-47877-5
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 440 Seiten, E-Book

A definitive, single source of information on PBPK modeling
Physiologically-based pharmacokinetic (PBPK) modeling is becomingincreasingly important in human health risk assessments and insupporting pharmacodynamic modeling for toxic responses. Organizedby classes of compounds and modeling purposes so users can quicklyaccess information, this is the first comprehensive reference ofits kind.
This book presents an overview of the underlying principles of PBPKmodel development. Then it provides a compendium of PBPK modelinginformation, including historical development, specific modelingchallenges, and current practices for:
* Halogenated Alkanes
* Halogenated Alkenes
* Alkene and Aromatic Compounds
* Reactive Vapors in the Nasal Cavity
* Alkanes, Oxyhydrocarbons, and Related Compounds
* Pesticides and Persistent Organic Pollutants
* Dioxin and Related Compounds
* Metals and Inorganic Compounds
* Drugs
* Antineoplastic Agents
* Perinatal Transfer
* Mixtures
* Dermal Exposure Models
In addition to pinpointing specific information, readers canexplore diverse modeling techniques and applications. Anauthoritative reference for toxicologists, ecotoxicologists, riskassessors, regulators, pharmacologists, pharmacists, and graduatestudents in pharmacokinetics and toxicology, Physiologically-BasedPharmacokinetic Modeling compiles information from leaders in thefield and discusses future directions for PBPK modeling.

Autoren/Hrsg.

Reddy, Micaela

Yang, R. S.

Andersen, Melvin E.

Clewell, III, Harvey J.

Über Autor(innen)

The EDITORS have worked together on PBPK research and in teachingPBPK modeling workshops and courses through the Quantitative andComputation Toxicology research group at the Center forEnviron-mental Toxicology and Technology (CETT) in the Departmentof Environmental and Radiological Health Sciences at Colorado StateUniversity (CSU).
MICAELA B. REDDY, PhD, is a research professor at CETT where shehas developed PBPK models for risk assessment and toxicologyapplications.
RAYMOND S. H. YANG, PhD, Professor of Toxicology and formerdirector, CETT, championed applications of PBPK modeling inresearch on the toxicology of chemical mixtures.
HARVEY J. CLEWELL III, MS, Director, Center for Human HealthAssessment, CIIT Centers for Health Research, Research TrianglePark, North Carolina, played a major role in the first uses of PBPKmodeling in cancer and non-cancer risk assessments by severalfederal agencies, including EPA, ATSDR, OSHA, and FDA.
MELVIN E. ANDERSEN, PhD, a pioneer in use of PBPK modeling intoxicology and risk assessment, is Director, Computational BiologyDivision, CIIT Centers for Health Research, Research Triangle Park,North Carolina.