Buch, Englisch, Band 70, 230 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 3693 g
Reihe: Subcellular Biochemistry
Buch, Englisch, Band 70, 230 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 3693 g
Reihe: Subcellular Biochemistry
ISBN: 978-94-024-0340-4
Verlag: Springer Netherlands
VOLUME I:
Here, we present the first volume of a multi-volume series on Retinoic Acid Signaling that will cover all aspects of this broad and diverse field. One aim of Volume I is to present a compilation of topics related to the biochemistry of nuclear retinoic acid receptors, from their architecture when bound to DNA and associated with their coregulators to their ability to regulate target gene transcription. A second aim is to provide insight into recent advances that have been made in identifying novel targets and non-genomic effects of retinoic acid. Volume I is divided into ten chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research.
Zielgruppe
Upper undergraduate
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
Weitere Infos & Material
Forward.- History of Retinoic Acid Receptors.- Architecture of DNA Bound RAR Heterodimers.- Retinoic Acid Receptors: Structural Basis for Coregulator Interaction and Exchange.- Evolution of Retinoic Acid Receptors and Retinoic Acid Signaling.- RXRs: Collegial Partners.- Nuclear and Extra-Nuclear Effects of Retinoic Acid Receptors: How they are interconnected- The Roles of Retinoic Acid and Retinoic Acid Receptors in Inducing Epigenetic Changes.- RARs and micro RNAs.- Integrative genomics to dissect retinoids functions.- Complexity of the RAR-Mediated Transcriptional Regulatory Programs.- Index.