Buch, Englisch, 1015 Seiten, Format (B × H): 192 mm x 261 mm, Gewicht: 2308 g
Buch, Englisch, 1015 Seiten, Format (B × H): 192 mm x 261 mm, Gewicht: 2308 g
ISBN: 978-1-4398-7210-9
Verlag: CRC Press
Divided into two sections, the book systematically assists pathologists in making a determination as to the origin and potential importance of a lesion and its relevance for assessing human risk. The first section includes eight "concept" chapters to orient pathologists in areas that are important for effective interaction with other pathologists as well as the many non-pathologists involved in drug development. The second section is made up of organ-based chapters, each including light microscopic and electron microscopic descriptions of pathological lesions, differential diagnoses, biological consequences, pathogenesis, mechanism of lesion formation, and the expected clinical pathology correlates.
This volume presents critical information—both published and unpublished and gained through personal experience—to improve the quality of drug safety evaluation and to expedite and improve the efficiency of the process. This book is crafted to assist students, residents, and toxicologic pathologists in their early career phase by serving as a resource that can effectively be used as a ready reference next to the microscope. In addition, more experienced pathologists will find this volume to be invaluable during their assessments. The book is also a valuable reference for toxicologists to assist in understanding compound-related pathological findings and to provide background for working on a range of toxicological problems.
Zielgruppe
Toxicologic pathologists in the pharmaceutical industry supporting contract research; pathologists and toxicologists in academia and regulatory agencies; veterinary and medical pathologists engaged in experimental pathology.
Autoren/Hrsg.
Fachgebiete
- Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
- Naturwissenschaften Biowissenschaften Toxikologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pathologie, Cytopathologie, Histopathologie
Weitere Infos & Material
Concepts in Drug DevelopmentOverview of Drug DevelopmentJames A. Popp and Jeffery A. EngelhardtNonclinical Safety Evaluation of DrugsThomas M. Monticello and Jeanine L. BussiereToxicokinetics and Drug DispositionDavid D. ChristIntroduction to Toxicologic PathologyJudit E. Markovits, Page R. Bouchard, Christopher J. Clarke, and Donald N. McMartinRoutine and Special Techniques in Toxicologic PathologyDaniel J. Patrick and Peter C. MannPrinciples of Clinical PathologyRobert L. HallToxicogenomics in Toxicologic PathologyMark J. Hoenerhoff and David E. MalarkeySpontaneous Lesions in Control Animals Used in Toxicity StudiesRobert C. Johnson, Robert H. Spaet, and Daniel L. PotentaOrgan SystemsGastrointestinal TractJudit E. Markovits, Graham R. Betton, Donald N. McMartin, and Oliver C. TurnerLiver, Gallbladder, and Exocrine PancreasRussell C. Cattley, James A. Popp, and Steven L. VonderfechtRespiratory SystemDavid J. Lewis and Tom P. McKevittUrinary SystemKendall S. Frazier and John Curtis SeelyHematopoietic SystemKristin Henson, Glenn Elliott, and Gregory S. TravlosLymphoid SystemPatrick J. HaleyBone, Muscle, and ToothJohn L. Vahle, Joel R. Leininger, Philip H. Long, D. Greg Hall, and Heinrich ErnstCardiovascular SystemCalvert Louden and David BrottEndocrine GlandsSundeep Chandra, Mark J. Hoenerhoff, and Richard PetersonReproductive System and Mammary GlandJustin D. Vidal, Michael L. Mirsky, Karyn Colman, Katharine M. Whitney, and Dianne M. CreasySkinZbigniew W. Wojcinski, Lydia Andrews-Jones, Daher Ibrahim Aibo, and Robert DunstanNervous SystemMark T. Butt, Robert Sills, and Alys BradleySpecial Senses: Eye and EarJames A. Render, Kenneth A. Schafer, and Richard A. Altschuler