Molecular Basis of Oxidative Stress

Chemistry, Toxicology, Disease Pathogenesis, Diagnosis, and Therapeutics
2. Auflage 2025
ISBN: 978-1-119-79026-6
Verlag: John Wiley & Sons Inc

Buch, Englisch, 560 Seiten, Format (B × H): 286 mm x 223 mm, Gewicht: 1538 g

In-depth resource on mechanisms of oxidative stress and damage and the role of free radicals in disease, diagnosis, and therapeutics

Molecular Basis of Oxidative Stress is a comprehensive resource on the molecular and chemical bases of oxidative stress, providing insight on various diseases caused by oxidative stress (cancer, cardiovascular, neurodegenerative) and the role of reactive oxygen species (ROS) in disease pathogenesis along with in-depth knowledge about the mechanisms of oxidative stress and damage, free radical chemistry, and the role of free radicals in disease, diagnosis, and therapeutics.

Thoroughly updated and expanded to reflect advances in the years since its original publication, the Second Edition includes new chapters covering topics like oxidative stress mechanisms, biomarkers, and therapeutic strategies in the management and treatment of diseases. The disease section features 10 new emerging diseases, including kidney and eye diseases and COPD.

This Second Edition also covers developments in the field in the last several years, such as an increase in mortality rate from air pollution and obstructive pulmonary diseases in which exogenous oxidants are initiators.

Written by a team of highly qualified academics, Molecular Basis of Oxidative Stress discusses sample topics including: - Classification, physico-chemical properties, sources, and detection of reactive species and etiology of COPD from cigarette smoke and pollution
- Oxidative, reductive and indirect non-redox modifications of key biomolecular systems such as lipids, proteins, and DNA by reactive species
- Gene expression of antioxidant defense enzymes, mitochondrial dysfunction and aberrant activation of NOX and cell signaling
- Biomarkers of oxidative stress in neurodegenerative diseases and emerging fields inbiomarker discovery such as cysteinylated albumin and nitroalkene fatty acids

Imparting strong foundational knowledge of redox chemistry, chemistry of oxidative damage and mechanisms of oxidative stress, and oxidative stress-mediated disease pathogenesis, Molecular Basis of Oxidative Stress is an essential reference for both novice and advanced toxicologists, biochemists, and pharmacologists, along with clinical and medical scientists in various fields such as oncology, cardiovascular, andneuroscience.

Autoren/Hrsg.

Villamena, Frederick A.

Forman, Henry Jay

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Chemie Organische Chemie Biochemie

Inhaltsverzeichnis

List of Contributors xxi

Preface to Second Edition xxix

Preface First Edition xxxi

1 Chemistry of Reactive Species 1
Frederick A. Villamena

1.1 Redox Chemistry 1

1.2 Classification of Reactive Species 2

1.3 Reactive Oxygen Species 4

1.4 Reactive Nitrogen Species 15

1.5 Reactive Sulfur and Chlorine Species 18

1.6 Reactivity 23

1.7 Origins of Reactive Species 27

1.8 Methods of Detection 32

References 39

2 Lipid Peroxidation and Nitration 49
Sean S. Davies and Lilu Guo

Overview 49

2.1 Peroxidation of PUFAs 49

2.2 Cyclic Endoperoxides and Their Products 52

2.3 Fragmented Products of Lipid Peroxidation 58

2.4 Epoxy Fatty Acids 62

2.5 Lipid Nitrosylation 62

Summary 65

References 65

3 Protein Posttranslational Modification 71
James L. Hougland Joseph Darling and Susan Flynn

Overview 71

3.1 Oxidative Stress-Related PTMs: Oxidation Reactions 71

3.2 Amino Acid Modification by Oxidation-Produced Electrophiles 80

3.3 Detection of Oxidative-Stress Related PTMs 81

3.4 Role of PTMs in Cellular Redox Signaling 84

Summary 85

References 85

4 DNA Oxidation 93
Dessalegn B. Nemera Amy R. Jones and Edward J. Merino

Overview 93

4.1 The Context of Cellular DNA Oxidation 93

4.2 Oxidation of Oligonucleotides 94

4.3 Examination of Specific Oxidative Lesions 96

Future Outlook of DNA Oxidative Lesions 103

References 103

5 Cellular Antioxidants and Phase 2 Proteins 113
Yunbo li

5.1 Definitions 113

5.2 Roles in Oxidative Stress 113

5.3 Molecular Regulation 117

5.4 Induction in Chemoprevention 119

5.5 Inactivation 119

References 121

6 Mitochondrial Dysfunction 129
Yeong-Renn Chen and Chwen-Lin Chen

6.1 Mitochondria and Submitochondrial P

Über Autor(innen)

Frederick A. Villamena, PhD, is an Associate Professor of Biological Chemistry and Pharmacology at The Ohio State University, College of Medicine.

Henry Jay Forman, PhD, is both Distinguished Professor Emeritus of Biochemistry at the University of California, Merced and Research Professor Emeritus of Gerontology at the University of Southern California Leonard Davis School of Gerontology.