Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays, m. 1 Buch, m. 1 E-Book, 2 Teile

Book + Online Access
2. Auflage 2013
ISBN: 978-3-642-25241-9
Verlag: Springer

Medienkombination, Englisch, 1404 Seiten, Book + Online Access, Format (B × H): 193 mm x 260 mm

-A landmark in the continuously changing world of drugs
-Essential reading for scientists and managers in the pharmaceutical industry involved in drug finding, drug development and decision making in the development process
-Of use for government institutions and committees working on official guidelines for drug evaluation worldwide

Zielgruppe

Research

Autoren/Hrsg.

Vogel, H. Gerhard

Maas, Jochen

Hock, Franz J.

Mayer, Dieter

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
• Wirtschaftswissenschaften Wirtschaftssektoren & Branchen Fertigungsindustrie Pharmaindustrie

Inhaltsverzeichnis

Safety PharmacokineticsAbsorption / in vitro Tests / Cell BasedAbsorption / in vitro Tests / Non Cell BasedAbsorption / in vivo Tests (Radiolabeled)Bioanalytical Assays - RIA/EIABioanalytical Assays / Gas Chromatography (GC)Bioanalytical Assays / LC-MS/MSBioanalytical Assays / ToxicokineticsClinical Studies / Typical DesignsDistribution - Across BarriersDistribution - in vivo - Perfused OrgansDistribution / in vitro Tests / Protein BindingDistribution / in vivo / Other MethodsDistribution in vivoDrug-drug Interaction / Enzyme InductionDrug-drug Interaction / Enzyme InhibitionIn silico ADME ModelingMetabolism Studies in vitro and in vivoPharmacogenomics in DMEPhysicochemical PropertiesPopulation PharmacokineticsSafety Pharmacokinetics: IntroductionTypical PK/PD Approaches in Preclinical and Clinical Development Safety PharmacologyAnalgesic Activity and Intravenous and Inhalation AnestheticsAnti-inflammatory and Antiarthrotic ActivityBiomaterials in Their Role in Creating New Approaches for the Delivery of Drugs, Proteins, Nucleic acids, and Mammalian cellsBlood ConstituentsCardiovascular PharmacologyCentral Nervous SystemChronobiology and the Implications for Safety PharmacologyCochlear Safety TestsDrug Safety on Herbal Medical ProductsDrug-Addiction and Drug-DependencyEndocrine PharmacologyMagnetic Resonance Imaging and Imaging in Pharmaceutical Safety AssessmentMetabolism PharmacologyOcular Safety TestsOncology PharmacologyPeripheral Nervous SystemPulmonary PharmacologyRenal SystemSafe Chemicals / REACHSafety Pharmacology in Biologics, Antibiotics and MonoclonicsSafety Pharmacology: Introduction and GuidelinesSensory SystemsSkin PharmacologyStem Cells in Safety PharmacologyStudy design and statisticsTransgenic AnimalsZebrafish Model Safety ToxicologyGenotoxicityIn silico MethodsIn vitro toxicity testingInternational GuidelinesOMICS TechnologiesReproductive ToxicologySafety Toxicology: IntroductionTesting of Medical DevicesTesting of Monoclonal AntibodiesToxicogenomicsAbsorption / in vitro Tests / Non Cell BasedAbsorption / in vivo Tests (Radiolabeled)Bioanalytical Assays - RIA/EIABioanalytical Assays / Gas Chromatography (GC)Bioanalytical Assays / LC-MS/MSBioanalytical Assays / ToxicokineticsClinical Studies / Typical DesignsDistribution - Across BarriersDistribution - in vivo - Perfused OrgansDistribution / in vitro Tests / Protein BindingDistribution / in vivo / Other MethodsDistribution in vivoDrug-drug Interaction / Enzyme InductionDrug-drug Interaction / Enzyme InhibitionIn silico ADME ModelingMetabolism Studies in vitro and in vivoPharmacogenomics in DMEPhysicochemical PropertiesPopulation PharmacokineticsSafety Pharmacokinetics: IntroductionTypical PK/PD Approaches in Preclinical and Clinical Development Safety PharmacologyAnalgesic Activity and Intravenous and Inhalation AnestheticsAnti-inflammatory and Antiarthrotic ActivityBiomaterials in Their Role in Creating New Approaches for the Delivery of Drugs, Proteins, Nucleic acids, and Mammalian cellsBlood ConstituentsCardiovascular PharmacologyCentral Nervous SystemChronobiology and the Implications for Safety PharmacologyCochlear Safety TestsDrug Safety on Herbal Medical ProductsDrug-Addiction and Drug-DependencyEndocrine PharmacologyMagnetic Resonance Imaging and Imaging in Pharmaceutical Safety AssessmentMetabolism PharmacologyOcular Safety TestsOncology PharmacologyPeripheral Nervous SystemPulmonary PharmacologyRenal SystemSafe Chemicals / REACHSafety Pharmacology in Biologics, Antibiotics and MonoclonicsSafety Pharmacology: Introduction and GuidelinesSensory SystemsSkin PharmacologyStem Cells in Safety PharmacologyStudy design and statisticsTransgenic AnimalsZebrafish Model Safety ToxicologyGenotoxicityIn silico MethodsIn vitro toxicity testingInternational GuidelinesOMICS TechnologiesReproductive ToxicologySafety Toxicology: IntroductionTesting of Medical DevicesTesting of Monoclonal AntibodiesToxicogenomicsBiomaterials in Their Role in Creating New Approaches for the Delivery of Drugs, Proteins, Nucleic acids, and Mammalian cellsBlood ConstituentsCardiovascular PharmacologyCentral Nervous SystemChronobiology and the Implications for Safety PharmacologyCochlear Safety TestsDrug Safety on Herbal Medical ProductsDrug-Addiction and Drug-DependencyEndocrine PharmacologyMagnetic Resonance Imaging and Imaging in Pharmaceutical Safety AssessmentMetabolism PharmacologyOcular Safety TestsOncology PharmacologyPeripheral Nervous SystemPulmonary PharmacologyRenal SystemSafe Chemicals / REACHSafety Pharmacology in Biologics, Antibiotics and MonoclonicsSafety Pharmacology: Introduction and GuidelinesSensory SystemsSkin PharmacologyStem Cells in Safety PharmacologyStudy design and statisticsTransgenic AnimalsZebrafish Model Safety ToxicologyGenotoxicityIn silico MethodsIn vitro toxicity testingInternational GuidelinesOMICS TechnologiesReproductive ToxicologySafety Toxicology: IntroductionTesting of Medical DevicesTesting of Monoclonal AntibodiesToxicogenomics

Über Autor(innen)

Hans Gerhard Vogel (1927-2011)H. Gerhard Vogel studied Pharmacy and Medicine at the Universities Erlangen and Tübingen (Germany). He received his Licensure as a Pharmacist in 1952 and as a Physician in 1956. His Doctorate in Medicine was gained in 1955. In 1963 he was designated a Fachpharmakologe DPhG. In 1967 he became Associate Professor in Pharmacology and Toxicology of the Department of Medicine, University of Marburg. In 1970 he was acknowledged as a Specialist for Pharmacology (Arzt für Pharmakologie). From 1972 he taught students of Medicine, Pharmacy and Biology as an Honorary Professor in Pharmacology and Toxicology of the Faculty of Medicine, University of Marburg and from 1979 as an Honorary Professor in Pharmacology and Toxicology of the Faculty of Medicine, University of Frankfurt. After working as a resident in medicine in a city hospital, he joined the Department of Pharmacology of Farbwerke Hoechst AG, Frankfurt as a pharmacologist and endocrinologist in 1958. In 1969 he was made Director of the Department of Pharmacology at Hoechst, in 1977 Head of Pharma Research Experimental Medicine, in 1980 Head of Pharma Research, Preclinical Evaluation and Development, and in 1989 Head of the Decision Board on Pharmaceutical Development. His scientific work was devoted to elaboration of new pharmacological methods, pharmacology of plant extracts from various countries, pharmacology of steroid hormones, pharmacology of peptide hormones, pharmacology of cardiac glycosides, biomechanics and biochemistry of connective tissue, experimental gerontology, experimental dermatology, development procedures for pharmaceutical products. He published more than 160 papers, mainly on new pharmacological methods, endocrinology, especially peptide endocrinology, biomechanics and biochemistry of connective tissue, such as skin and bone, and on other topics. He was a member of many international and national scientific societies, such as The New York Academy of Science, American Association for the Advancement of Science, German Society of Experimental and Clinical Pharmacology and Toxicology, International Society for Bioengineering and the Skin, European Association for the Study of Diabetes, German Society of Endocrinology, German Society of Diabetology, German Society Connective Tissue Research, German-Chinese Society of Medicine. He was a co-editor and contributor to several scientific textbooks. In 1997 he published together with Wolfgang H. Vogel the book Drug Discovery and Evaluation. Pharmacological Assays (Springer-Verlag), which appeared in a second completely revised, updated and enlarged edition with many contributions by his colleagues in 2002. A third edition was published in 2008. Editorial Board:Franz Jakob HockFranz Jakob Hock received his Ph.D. degree (Sc.D.) in Zoology at the Institute of Neuroethology and Biocybernetics at the University of Kassel, Germany. He joined the Department of Pharmacology of the pharmaceutical company Hoechst AG in 1976. He initially worked on methods in general pharmacology and nephrology, before becoming head of a laboratory devoted to pharmacological methods for drugs in uencing memory and learning. He was then appointed Head of the Laboratory of General and Safety Pharmacology at the Frankfurt site of Aventis Pharma Deutschland GmbH. He received the degree of Fachpharmakologe DGPT ("certified expert pharmacology") in 1981. In 1983 he spent a sabbatical year at the University of California, Irvine, at the Center for the Neurobiology of Learning and Memory (Director Prof. Dr. James L. McGaugh). He lectured for several years to students in Biology at the University of Kassel and the Technical University Darmstadt. He has published over 100 original papers on methods in Pharmacology and on new compounds. He is currently a member of the Task Force General/Safety Pharmacology German/Swiss Pharmaceutical Companies. He served several times a