Solid-Phase Synthesis

A Practical Guide
1. Auflage 2000
ISBN: 978-0-8247-0359-2
Verlag: Taylor & Francis Inc

Buch, Englisch, 848 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 1225 g

This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds for drug discovery and analyzes peptides, DNA, carbohydrates, conjugates of biomolecules, and small molecules.

Zielgruppe

Academic and Professional Practice & Development

Autoren/Hrsg.

Albericio, Fernando

Fachgebiete

• Naturwissenschaften Chemie Anorganische Chemie Festkörperchemie
• Naturwissenschaften Chemie Organische Chemie Polymerchemie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)

Inhaltsverzeichnis

The solid support strategy in solid-phase synthesis; amino acids -alpha-amino protecting groups; side-chain protecting groups; solid supports for the synthesis of peptides and small molecules; coupling methods - solid-phase formation of amide and ester bonds; homodetic cyclic peptides; disulfide formation in synthetic peptides and proteins -the state of the art; solid-phase convergent approaches to the synthesis of native peptides and proteins; preparation of glyco-, phospho-, and sulfopeptides; oligonucleotide synthesis; synthesis of oligonucleotide-peptide conjugates and nucleopeptides; the chemistry of peptide nucleic acids; solid-phase synthesis of pseudopeptides and oligomeric peptide backbone mimetics; instrumentation; the purification of synthetic peptides; analysis of synthetic peptides; the chromatographic analysis of combinational arrays - parallel HPLC and HPLC-MS.

Über Autor(innen)

Steven A. Kates, Fernando Albericio