The Comprehensive Sourcebook of Bacterial Protein Toxins

4th Revised Auflage
ISBN: 978-0-12-800188-2
Verlag: Elsevier Science

Buch, Englisch, 120 Seiten, Format (B × H): 160 mm x 233 mm, Gewicht: 2008 g

The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content.

Zielgruppe

Scientists and students of toxinology, microbiology, cell biology and biochemistry, as well as medical students, physicians, pathologists and those involved in the management of bioterrorism threats.

Autoren/Hrsg.

Alouf, Joseph E

Ladant, Daniel

Popoff, Michel R.

Fachgebiete

• Naturwissenschaften Biowissenschaften Bakteriologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Naturwissenschaften Astronomie Exobiologie, Astrobiologie, Xenobiologie
• Naturwissenschaften Biowissenschaften Toxikologie
• Naturwissenschaften Biowissenschaften Biowissenschaften Exobiologie, Astrobiologie

Inhaltsverzeichnis

Section I: Basic Genomic and Physiological Aspects of Bacterial Protein Toxins1. Evolutionary aspects of toxin-producing bacteria2. Mobile genetic elements and pathogenicity islands encoding bacterial toxins3. News and views on protein secretion systems

Section II: Intracellularly Alive Bacterial Protein Toxins4. Diphtheria toxin5. Pseudomonas aeruginosa toxins6. Bordetella protein toxins 7. Vibrio cholerae and Escherichia coli heat-labile enterotoxins and beyond 8. Vibrio parahaemolyticus virulence determinants 9. Typhoid toxin10. Shiga toxins: properties and action on cells11. Clostridial neurotoxins: from the cellular and molecular mode of action to their therapeutic use12. Uptake and transport of clostridial neurotoxins 13. Bacillus anthracis toxins 14. ADP-ribosylating toxins modifying the actin cytoskeleton 15. Large clostridial cytotoxins modifying small GTpases: structural aspects 16. Large clostridial glycosylating toxins modifying small GTPases: cellular aspects 17. Pasteurella multocida toxin 18. Deamidase toxins 19. Helicobacter pylori vacuolating toxin 20. Bacterial genotoxins

Section III: Bacterial Protein Toxins Active on the Surface of Target Cells 21. Basic mechanism of pore-forming toxins 22. Membrane-damaging and cytotoxic sphingomyelinases and phospholipases 23. Structure and function of RTX toxins 24. Perfringolysin O and related cholesterol-dependent cytolysins: mechanism of pore formation 25. The staphylococcal alpha-toxin and leukotoxins 26. Aerolysin and Related Aeromonas Toxins 27. Structural relationships between small ß-pore-forming toxins from Clostridium perfringens 28. Clostridium perfringens enterotoxin 29. Bacillus cereus phospholipases, enterotoxins, and other hemolysins 30. Mechanism of action of Bacillus thuringiensis insecticidal toxins and their use in the control of insect pests 31. Escherichia coli heat-stable enterotoxins 32. Bacterial superantigens and superantigen-like toxins

Section IV: Clinical Aspects, Applications of Bacterial Protein Toxins in Cell Biology and Therapy, and Toxin Inhibitors 33. Clostridial toxins in the pathogenesis of gas gangrene 34. Engineering of botulinum neurotoxins as novel therapeutic tools 35. Engineering of bacterial toxins for research and medicine 36. Toxins as tools 37. Exploiting endocytic pathways to prevent bacterial toxin infection 38. Inhibitors of pore-forming toxins 39. Bacterial protein toxins as biological weapons

Über Autor(innen)

Popoff, Michel R.
Michel R. Popoff, D.V.M., Ph.D. (Microbiology) from the University of Paris (1985), Habilitation à Diriger des Recherches (HDR) from the University of Paris (1990), is the Head of the Anaerobic Bacteria and Toxins Unit and the Director of the National Reference Center for Anaerobic Bacteria and Botulism at Pasteur Institute, Paris, France. He is member of the French Veterinary Academy. His laboratory is focused on Clostridium toxins through genetic and biological activity analysis and has investigated the regulation of toxin synthesis in Clostridium botulinum and Clostridium tetani. In the recent years, we have analyzed the molecular mechanism of the actin depolymerizing C. sordellii lethal toxin and clostridial binary toxins, the pore-forming C. perfringens epsilon toxin, and the passage of botulinum neurotoxin through the intestinal barrier. He was co-editor of the 3° edition of the Sourcebook of Bacterial Protein Toxins Academic Press (2006).

Alouf, Joseph E
Joseph E. Alouf is Professor of Microbiology at the Pasteur Institute of Lille. He is former Head of the Department of Bacteriology and Mycology at the Pasteur Institute at Paris and Chairman of its Scientific Council. He served as Secretary General of the French Society of Immunology from 1984-1986 and President of the Federation of the European Microbiological Societies from 1989-1992. His 40-year research work relates to the field of bacterial protein toxins and immunology of infectious diseases. He is also the co-editor of several books.