Flow and Microreactor Technology in Medicinal Chemistry

1. Auflage 2022
ISBN: 978-3-527-34689-9
Verlag: WILEY-VCH

Buch, Englisch, 350 Seiten, Format (B × H): 170 mm x 244 mm, Gewicht: 842 g

Reihe: Methods and Principles in Medicinal Chemistry

Computer-controlled chemical synthesis using flow chemistry microreactors is the key enabling technology for the chemistry laboratory of the future. Early adopters of this ground-breaking technology describe current and future uses in medicinal chemistry.

Autoren/Hrsg.

Alza, Esther

Mannhold, Raimund

Buschmann, Helmut

Holenz, Jörg

Weitere Mitwirkende

Mannhold, Raimund

Buschmann, Helmut

Holenz, Jörg

Fachgebiete

• Naturwissenschaften Chemie Analytische Chemie Instrumentelle Analytik, Chromatographie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Chemische Verfahrenstechnik

Inhaltsverzeichnis

Chemistry at the Extremes: Turning Complex Reactions into Scalable Processes
Automated Flow Chemistry Platforms
Flow Chemistry Opportunities for Drug Discovery
Flow Chemistry in Medicinal Chemistry - Applications to Bcr-Abl Kinase Inhibitors
Integrated Systems for Continuous Synthesis and Biological Screenings
Application of Continuous Flow Processing in Multistep API and Drug Syntheses
Continuous Flow Multistep Synthesis of Active Pharmaceutical Ingredients
Enantioselective (Bio)Catalysis in Continuous-Flow as Efficient Tool for the Synthesis of Advanced Intermediates and Active Pharmaceutical Ingredients
Innovative Process Development of Pharmaceutical Intermediates Under Continuous-Flow System

Über Autor(innen)

Esther Alza is the Manager of ERTFLOW at the Institute of Chemical Research of Catalonia (ICIQ), in Tarragona, Spain. Having obtained her PhD from ICIQ working on asymmetric catalysis and flow chemistry, she moved to the University of Cambridge as a Wellcome Trust Postdoctoral Fellow to work on medicinal chemistry. After this, she returned to ICIQ to lead the establishment of ERTFLOW as technology development unit and future spin-off company.