Buch, Englisch, Format (B × H): 152 mm x 229 mm, Gewicht: 450 g
Buch, Englisch, Format (B × H): 152 mm x 229 mm, Gewicht: 450 g
ISBN: 978-0-443-52233-8
Verlag: Elsevier Science & Technology
Arginase: Structure, Function, and Therapeutic Targeting, Volume 740 in the Methods in Enzymology series, provides a comprehensive, methodology-driven perspective on arginase research spanning molecular, biochemical, and translational domains. Chapters in this new release include Expression, Purification, and Structural Characterization of Human and Leishmania Arginase with Comparative Analysis of Structures from the Protein Data Bank, Synthesis of First-Generation Arginase Inhibitors, Computational and Structure-Guided Design of Arginase Inhibitors, Metal Substitution in Arginase: Experimental Approaches to Study Metal-Dependent Catalysis, Therapeutic Arginase Formulations: PEGylation, Stability, and Advanced Delivery Systems, and much more.
Additional chapters cover Dual ARG1/ARG2 Inhibition: Experimental and Structural Strategies for Inhibitor Design and Optimization, Synthesis of Second-Generation Arginase Inhibitors, Cryo-EM Workflow and Structural Characterization of Arginase–Antibody Complexes, Development and Validation of an Electrochemical Assay for Arginase Activity, Experimental and Structural Analysis of H. pylori Arginase in Gastric Immune Evasion, Agmatinase and Alternative Arginine Utilization Pathways in Bacteria: Biochemical and Functional Perspectives, Catalytic Diversification of the Arginase Fold: Structural and Mechanistic Insights from DcsB, Beyond Arginase: Structural Biology of the Extended Guanidinase Family, Plant Arginase: Structural and Functional Roles in Nitrogen Metabolism, and much more.
Fachgebiete
Weitere Infos & Material
Section I: Molecular and Structural Approaches to Arginase Function and Inhibition
1. Expression, Purification, and Crystallization of Human and Leishmania Arginase
Edward Lawrence D'Antonio, Luigi Franklin Di Costanzo and David W. Christianson
2. Systematic Structural Analysis of Arginase and the Expanded Arginase-Fold Superfamily Using the Protein Data Bank
Luigi Franklin Di Costanzo, David W. Christianson and Edward Lawrence D'Antonio
3. Synthetic Protocols for First- and Second-Generation Arginase Inhibitors
F. Sodano, Marica Erminia Schiano, C. Battisegola and Maria Cristina Molaro
4. Computational and Experimental Strategies for the Discovery of Non-Boronic Arginase I Inhibitors
Symon Gathiaka and Luigi Franklin Di Costanzo
5. Computational and Structure-Guided Design of Arginase Inhibitors
M.A. Fumagalli
Section II: Advanced Therapeutic Strategies and Analytical Methods for Arginase
6. Therapeutic Engineering of Human Arginase 1: Design, Manufacturing, and Clinical Translation of Pegzilarginase
Leslie S. Sloan and Mattias Rudebeck
7. Dual ARG1/ARG2 Inhibition: Experimental and Structural Strategies for Inhibitor Design and Optimization
Marcin Mikolaj Grzybowski, Roman Blaszczyk and Zbigniew Zaslona
8. Synthetic Protocols for Third- and Fourth-Generation Arginase Inhibitors
F. Sodano, Marica Erminia Schiano, C. Battisegola and Maria Cristina Molaro
9. Cryo-EM Workflow and Structural Characterization of Arginase–Antibody Complexes
Giovanna Scapin
10. Development and Validation of an Electrochemical Assay for Arginase Activity
Antonella Miglione, Luigi Franklin Di Costanzo and Stefano Cinti
11. Fluorometric Arginase Assay Utilizing a Urease and L-Glutamate Dehydrogenase Coupled System
Edward Lawrence D'Antonio, Matheson J. Bray and Lindsey R. Baker
Section III: Clinical, Metabolic, and Translational Aspects of Arginase
12. Experimental and Structural Analysis of H. pylori Arginase in Gastric Immune Evasion
Apurba Kumar Sau
13. Alternative Arginine Utilization Pathways in Bacteria: Identifying and Assaying Agmatinase and Agmatine Deiminase Activity
J. French, Katherine Hicks and Faisal Aziz
14. Arginase Deficiency and Other Inherited Urea Cycle Disorders
N. Brunetti-Pierri
15. Arginase in Vascular Disease: Mechanisms, Measurement, and Medicine
William Durante
Section IV: Evolutionary and Functional Diversity of Arginase and Related Enzymes
16. Catalytic Diversification of the Arginase Fold: Structural and Mechanistic Insights from DcsB
Yasuyuki Matoba and Kosuke Oda
17. Arginase in Plants: Structural and Functional Roles in Nitrogen Metabolism
Bartosz Sekula, Maciej Nielipinski, Agnieszka Pietrzyk-Brzezinska, Kacper Zielak and Joanna Nowicka
18. Structural and Biochemical Characterization of Non-Canonical Arginases: Oligomerization, Metal Coordination, and Functional Diversity
Suk-Youl Park, Ji-Won Kim and Jeong-Sun Kim
