Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders

Erscheinungsjahr 2015
ISBN: 978-0-12-800228-5
Verlag: Elsevier Science

Buch, Englisch, 450 Seiten, Format (B × H): 196 mm x 236 mm, Gewicht: 1111 g

Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders presents a state-of-the-art review of the effects of environmental contaminants on the development and degeneration of the human nervous system, brought together by world-leading experts in the field.

Part One describes the adverse effects that the environment can have on neurological development, and how these effects may exhibit. Specific contaminants and their possible consequences of exposure are addressed (lead, methylmercury, alcohol), as well as specific disorders and the environmental factors associated with them, such as the effect of diet on attention deficit and hyperactivity disorders. Part Two tackles neurodegenerative disorders, specifically addressing their potential neurotoxic origins, and discussing the increasing interest in the effects that early exposure may have in later life.

Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders is an invaluable reference for those professionals working in the fields of toxicology, environmental health and neuroscience.

Zielgruppe

Professional toxicologists, environmental health scientists, neuroscientists, professors, postgraduate students and legislative professionals who work with neurotoxicology

Autoren/Hrsg.

Aschner, Michael

Costa, Lucio G

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Umweltfaktoren in der Medizin
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Umweltmedizin, Arbeitsmedizin, Tropenmedizin, Sportmedizin Umweltmedizin
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

Preface Foreword by Annette Kirshner

Section I: Neurodevelopmental Disorders

1. Overview of the Role of Environmental Factors in Neurodevelopmental Disorders 2. Genetic Factors in Environmentally-Induced Disease 3. Fetal Alcohol Spectrum Disorders 4. Prenatal Infection 5. Attention Deficit-Hyperactivity Disorders 6. Organic Mercury Compounds 7. Lead 8. Endocrine Disruptors 9. Summary and Perspectives 10. Overview of Environmental Factors in Neurodegenerative Disorder

Part II: Neurodegenerative Disorders

11. Western Pacific ALS-PDC: a Prototypical Long-Latency Environment Neurodegenerative Disorder 12. Parkinson's Disease Epidemiology 13. Parkinson's Disease: Mechanisms and Biological Plausibility 14. Genetics of Parkinson's Disease 15. Environmental Risk Factors in Alzheimer Disease 16. Amyotrophic Lateral Sclerosis: Environmental Factors 17. Gene-Environment Interactions in Huntington's Disease 18. Infection, Neuroinflammation and Neurodegenerative Diseases 19. Late Effects of Early Exposures 20. Summary and Perspectives

Über Autor(innen)

Aschner, Michael
Dr. Michael Aschner is currently the Harold and Muriel Block Chair in Molecular Pharmacology at Albert Einstein College of Medicine where he is also a Professor in the Departments of Molecular Pharmacology, Neuroscience, and Pediatrics. He is a leading expert in neurotoxicology and neurodevelopmental and neurodegenerative diseases. In addition to serving as a past president of the Society of Toxicology (2022-23), he served on numerous toxicology panels (U.S. EPA and CDC), been an expert reviewer for multiple federal agencies in the US and abroad, and is a member of the Neurotoxicology and Alcohol study section (NIH). He is a past recipient of the prestigious Society of Toxicology Merit Award (2010) and the Distinguished Neurotoxicologist Award (2020). He is a co-editor of the Elsevier series, Advancements in Neurotoxicology in addition to edited other Elsevier titles. He has published numerous articles and has served as an associate editor for multiple high impact factor journals.

Costa, Lucio G
Dr. Lucio G. Costa is Professor of Toxicology at the University of Washington in Seattle, and of Pharmacology/Toxicology at the University of Parma Medical School. He received a doctorate in Pharmacology from the University of Milano in 1977, and was a postdoctoral fellow at the University of Texas at Houston. He is a member of several national and international professional organizations, a Fellow of the Academy of Toxicological Sciences, and a European Certified Toxicologist. He received various award for his scientific accomplishments, including the Achievement Award from the Society of Toxicology. He serves in various editorial capacities for several toxicology journals, and is an active manuscript and grant reviewer. Dr. Costa has been the member of dozens of panels and committees at the national and international level dealing with toxicology and risk assessment issues. He has chaired and/or organized symposia at scientific meetings in the United States and internationally. He has been teaching classes in the area of toxicology, neurotoxicology and pharmacology to graduate and medical students for 30 years. He keeps an active research program in the area of neurotoxicology.