3D Bioprinting and Bioinks for Regenerative Engineering

Current Concepts and Future Advances
Erscheinungsjahr 2027
ISBN: 978-0-443-45603-9
Verlag: Elsevier Science

Buch, Englisch, 500 Seiten, Format (B × H): 191 mm x 235 mm

3D Bioprinting and Bioinks for Regenerative Engineering: Current Concepts and Future Advances covers bioinks and their associated materials, design formulations, biological interactions, commercial products, and diverse applications in regenerative engineering of various tissues and organs. Part I lays the foundation for bioink concepts and their significance. Part II delves into various 3D printing technologies that enable the creation of complex biological structures. Part III focuses on the fundamentals of bioinks—critical materials that play a key role in printing viable tissues. In Part IV, attention shifts to the process of printing and the development of tissue and organ constructs.

Finally, Part V addresses regulatory considerations and offers insights into future perspectives, emphasizing the challenges and opportunities ahead as the field continues to evolve. As the field is on the verge of a new era in engineering tissues, and tissue/body on a chip technologies will play a central role, bioinks are becoming a multidisciplinary field involving materials science, cell biology, biofabrication, and clinical applications. By combining cutting-edge research, practical applications, and expert contributions, this book will become an indispensable resource for both newcomers and experienced professionals.

Autoren/Hrsg.

Atala, Anthony

Lim, Jeong Ok

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften

Inhaltsverzeichnis

Part I: Introduction
1. History and Evolution of 3D Printing and Bioinks in Regenerative Engineering

Part II: 3D Printing Technologies
2. Extrusion-Based Printing
3. Jetting-Based Printing
4. Light-Based Printing
5. Hybrid Printing
6. Automation and Robotics in Bioprinting
7. Multiphoton Lithography and Emerging Precision

Part III: Fundamentals of Bioinks for 3D Printing
8. Introduction to Bioinks
9. Nature-Derived Hydrogel Bioinks
10. Synthetic Polymer Bioinks
11. Composite Bioinks
12. Bioink Formulations and Design
13. Self-Assembling Bioinks
14. Cellular Aggregates ad Spheroids as Building Blocks
15. Green Processing and Lifecycle Considerations for Bioinks
16. Preservation and Sterilization of Bioinks
17. Manufacturing and Translational Perspectives of Bioinks

Part IV: Printing Tissue and Organ Constructs
18. Skin
19. Cartilage
20. Muscle
21. Bone
22. Kidney
23. Pancreas
24. Liver
25. Lung
26. Trachea
27. Heart
28. Brain
29. Gastrointestinal Structures
30. Craniofacial Structures
31. Oral Cavity
32. Reproductive Structures
33. Urologic Structures
34. Vascular Structures
35. Immune Systems
36. Nerve

Part V: Regulatory Considerations and Future Perspectives
37. Regulatory Pathways for 3D Bioprinted Products
38. Ethical and Societal Dimensions of 3D Printing
39. Innovations in Body-on-a-Chip Systems
40. Bioprinting in Space: Opportunities and Challenges

Über Autor(innen)

Lim, Jeong Ok
Dr. Lim’s research interests encompass tissue engineering, biofabrication, regenerative engineering, and controlled drug delivery systems. Her work has been widely recognized, with over 150 peer-reviewed publications and numerous patents, some of which have been licensed to companies. Dr. Lim has been honored with prestigious awards such as the TERMIS International Fellow Award and KTERMS Award, highlighting her contributions to the field. Dr. Lim has delivered over 160 invited presentations worldwide and has played key roles in various academic and professional organizations, including serving as President of the Korea Tissue Engineering and Regenerative Medicine Society and as a TERMIS Fellow. Her editorial roles span several leading journals, including Tissue Engineering and Regenerative Medicine, where she has served as an Editorial Board Member and Associate Editor. Dr. Lim has held academic appointments at Wake Forest University School of Medicine, where she is currently a Professor in the Department of Regenerative Medicine.

Atala, Anthony
Anthony Atala, MD, is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine. Seventeen of his lab’s technologies have been translated to patients, including the first tissue-engineered organ for permanent implantation in a human. His research led to the discovery of a multipotent source of stem cells from amniotic fluid and placenta, advances in 3D printing of tissues and organs, and body-on-a-chip technologies. His work was twice listed among Time Magazine’s top 10 medical breakthroughs of the year, and he is a recipient of the Smithsonian Ingenuity Award. He has published over 900 journal articles, is the editor of 25 books, and holds over 250 national and international patents. Dr. Atala is a member of the National Academy of Medicine, the National Academy of Inventors, and the American Institute for Medical and Biological Engineering.