Genetics of Obesity Syndromes

Erscheinungsjahr 2008
ISBN: 978-0-19-530016-1
Verlag: Oxford University Press

Buch, Englisch, 304 Seiten, Print PDF, Format (B × H): 161 mm x 240 mm, Gewicht: 617 g

Obesity is one of the most important contributing factors to disease throughout the world and is an area of great current interest among researchers and clinicians. The genetics of common obesity is complex, and an important thread through this labyrinth is the study of genetic syndromes in which obesity is a major component. By examining the genetic mechanisms of obesity in these syndromes, the authors will shed new light on the genetics of common obesity. This is the first book on this important and exciting new area and addreses both the molecular and clinical features of the obesity syndromes, providing hard-core information for researchers and practical guidelines for clinicians caring for obese patients.
The book is divided into three sections: the first covers approaches for assessing and investigating the obese individual; the second describes nondysmorphic, monogenic forms of obesity; and the third documents key, multisystem obesity syndromes with various genetic etiologies. It is as much a reference book as it is a manual and will appeal to clinical geneticists, obesity researchers, endocrinologists, nutritionists, and medical biologists.

Autoren/Hrsg.

Beales, Philip R.

Farooqi, I. Sadaf

O'Rahilly, Stephen

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Essstörungen & Therapie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik

Inhaltsverzeichnis

- Section I

- 1: Phillip L. Beales, Sadaf Farooqi: Introduction

- 2: Sadaf Farooqi: A Practical Guide to the Clinical Assessment and Investigation of Obesity

- Section II: Non-Syndromic Obesity

- 3: Sadaf Farooqi, Stephen O'Rahilly: Leptin and Leptin Receptor Deficiency

- 4: Heike Krude: Pro-opiomelanocortin Deficiency

- 5: Robert S. Jackson: Prohormone Convertase

- 6: Sadaf Farooqi, Stephen O'Rahilly: Melanocortin 4 Receptor Deficiency

- Section III: Syndromic Obesity

- 7: Louise C. Wilson: Albrights Hereditary Osteodystrophy, Pseudoparathyroidism and Other GNAS Associated Syndromes

- 8: Gayle B. Collin, Jan D. Marshall, Jürgen K. Naggert, Patsy M. Nishina: The Clinical and Molecular Genetics of Alström Syndrom

- 9: Alison Ross, Phillip L. Beales, and Josephine Hill: The Clinical, Molecular, and Functional Genetics of Bardet-Biedl Syndrome

- 10: Joanna Crawford, Michael Partington, Mark Corbett, Karen Lower, Jozef Gécz: The Börjeson-Forssman-Lehmann Syndrome

- 11: Kate E. Chandler, F.D.C. Manson: The Cohen Syndrome

- 12: Rachel Wevrick: Prader-Willi Syndrome

- 13: Phillip L. Beales, Raoul Hennekam: Syndromes with Obesity