Clinical Trial Simulations using R

1. Auflage 2023
ISBN: 978-1-4987-3415-8
Verlag: Taylor & Francis Inc

Buch, Englisch, 508 Seiten, Format (B × H): 156 mm x 234 mm

Reihe: Chapman & Hall/CRC Biostatistics Series

Trial simulations provide a very useful tool in planning and designing successful clinical trials. Because so many different variables go into the design, conduct, and outcome of a trial, using simulations to test different scenarios can help optimize trial parameters, including factors such as sample size, endpoint selection, observation timing, dosing regimen, along with many others. provide a This book will provide a simple trial simulation tool kit using the open source software R that the reader can immediately put to use.

Autoren/Hrsg.

Berry, Seth

Reeve, Russell

Inhaltsverzeichnis

Writing trial simulation plans. Developing models for trial simulation. Blue prints of trial design. Building the virtual patient population. Study design and conduct models. Incorporation of the drug model. Optimizing the trial statistical analysis. Designing the simulation experiments using response surface methodologies. Maximizing the probability of success. Summarizing and reporting trial simulation results