Biosynthesis

Erscheinungsjahr 2027
ISBN: 978-0-443-52245-1
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 152 mm x 229 mm

In this volume on Biosynthesis, we focus on “unusual enzyme reactions in natural products biosynthesis”. We used the broadest possible definition of the scope of mechanistic biology and biosynthesis to bring in contributors from diverse scientific areas. The articles presented here survey a broad range of enzyme reactions in natural product biosynthesis. We appreciate the valuable contributions from all the authors, and hope that readers can enjoy and learn a lot from these articles.

Autoren/Hrsg.

Weitere Mitwirkende

Christianson, David

Allen, Karen N.

Abe, Ikuro

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Physik Angewandte Physik Biophysik

Inhaltsverzeichnis

1. Experimental approaches for studying heme-oxygenase-like diiron enzymes acting on tryptophan
Bradley Moore, Sanjoy Adak and Maria-Eirini Pandelia
2. Heme-dependent enzyme
Katherine Ryan
3. Multinuclear ion-dependent oxidation enzymes (MNIOs)
Wilfred van der Donk
4. The ThDP-dependent enzymes in alpha-keto acids coupling reactions
Ming Ma
5. Methylation-triggered terpene cyclizations
Jeroen Dickschat and Kexin Yang
6. Discovery and Biochemical Characterization of Pseudo-Sugar Transfer Enzymes
Taifo Mahmud, Takeshi Tsunoda and Shumpei Asamizu
7. Depside Bond-Forming Reactions in Polyketide Synthases
Yudai Matsuda
8. Functional characterization of a Rieske oxygenase in aeruginosin biosynthesis
Richiro Ushimaru
9. Biocatalytic Synthesis of a-Hydrazino Acid Derivatives by Cupin Metalloenzymes
Kenichi Matsuda
10. Larg NRPS/PKS enzymes
Hui-Ming Ge
11. P450 enzyme
Shengying Li
12. Terpene cyclase
Hsiao-Ching Lin
13. NAD Metabolizing Enzyme
Takayoshi Awakawa
14. F420-dependent reactions in biosynthesis of secondary metabolites
Ghader Bashiri
15. Structure, function, and engineering of pyridoxal-5'-phosphate dependent enzymes
Takahiro Mori
16. SwnH2 and SwnH1 from the swainosnine pathway
Yang Hai, Wenhui Xi and Shubin Mou
17. Incorporation of Sulfur Catalyzed by the Radical SAM Enzyme MybB during the Biosynthesis of Mycobacidin
Hung-wen Liu, Houyuan Zhao and Junling Bu
18. Nonheme Fe/2OG enzymes
Wei-chen Chang, Yaoyao Shen, Kuo Wang, Philp M. Palacios and Yisong Guo
19. NRPS (FR900359 side chain assembly and transesterification)
Max Crüsemann
20. Non-ribosomal peptide synthetase
Wen Liu, Yanan Du and Yijiao Xiong
21. CAH-like plant enzyme
Ryan S. Nett and Jaime Martinez Grundman
22. Rieske oxygenase
Jennifer D. Bridwell-Rabb

Über Autor(innen)

Christianson, David
After completing studies for the A.B., A.M., and Ph.D. degrees in chemistry at Harvard University, David W. Christianson joined the faculty of the University of Pennsylvania, where he is currently the Roy and Diana Vagelos Professor in Chemistry and Chemical Biology. At Penn, Christianson’s research focuses on the structural and chemical biology of the zinc-dependent histone deacetylases as well as enzymes of terpene biosynthesis. His research accomplishments have been recognized by several awards, including the Pfizer Award in Enzyme Chemistry and the Repligen Award in Chemistry of Biological Processes from the American Chemical Society, a Guggenheim Fellowship, and the Elizabeth S. and Richard M. Cashin Fellowship from the Radcliffe Institute for Advanced Study at Harvard University. Christianson is also a dedicated classroom teacher, and his accomplishments in this regard have been recognized by the Lindback Award for Distinguished Teaching at Penn and a Rhodes Trust Inspirational Educator Award from Oxford University. Christianson has also held visiting professorships in the Department of Biochemistry at Cambridge University and the Department of Chemistry and Chemical Biology at Harvard University. Christianson has served with Prof. Anna Pyle as Co-Editor-in-Chief of Methods in Enzymology since 2015.

Abe, Ikuro
Ikuro Abe is Professor of Natural Products Chemistry at Graduate School of Pharmaceutical Sciences, The University of Tokyo (since 2009). He received his B.S. (1984) and Ph.D. (1989) from The University of Tokyo. After two years postdoctoral research with Professor Guy Ourisson at the CNRS Institut de Chimie des Substances Naturelles, and mostly with Professor Michel Rohmer at the Ecole Nationale Supérieure de Chimie de Mulhouse in France (1989-1991), he moved to the USA to work with Professor Glenn D. Prestwich at the State University of New York at Stony Brook (1991-1996) and then at the University of Utah (1996-1998). His research interests mostly focus on exploring and engineering the natural products biosynthesis. He received several awards, including Prizes for Science and Technology by the MEXT Japan (2019) and Medal with Purple Ribbon, Cabinet Office, Government of Japan (2025).

Allen, Karen N.
Dr. Karen N. Allen works at the Department of Chemistry of the Boston University, the Metcalf Center for Science and Engineering