Basic Principles of Drug Discovery and Development

2. Auflage 2021
ISBN: 978-0-12-817214-8
Verlag: Elsevier Science Publishing Co Inc

Buch, Englisch, 712 Seiten, Format (B × H): 152 mm x 227 mm, Gewicht: 1152 g

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics.

Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator's fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist's early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process.

Zielgruppe

<p>Upper level undergraduate students, graduate students interested in drug discovery research, chemistry, biology, pharmacology, biochemistry, toxicology, formulations, discovery/development of new therapeutic agents; pharmaceutical industry; FDA, public policy groups interested in influencing the pharmaceuticals industry; business analysts, entrepreneurs, venture capitalist interested in investing in the pharmaceuticals industry</p>

Autoren/Hrsg.

Blass, Benjamin E.

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie

Inhaltsverzeichnis

1. Drug Discovery and Development: An Overview of Modern Methods and Principles 2. The Drug Discovery Process: From Ancient Times to the Present Day 3. Classical Targets in Drug Discovery 4. In Vitro Screening Systems 5. Medicinal Chemistry 6. In vitro ADME and In vivo Pharmacokinetics 7. Animal Models of Disease States 8. Safety and Toxicology 9. Antibody Drug Discovery 10. Basics of Clinical Trials 11. Translational Medicine and Biomarkers 12. Organizational Considerations and Trends in the Pharmaceutical Industry 13. Intellectual Property and Patents in Drug Discovery 14. Case Studies in Drug Discovery

Über Autor(innen)

Blass, Benjamin E.
As an industrial medicinal chemist, Dr. Blass has experience with major pharmaceutical organizations (Wyeth, Procter & Gamble Pharmaceuticals) and small biotech operations (Fox Chase Chemical Diversity Center), which provided him with a wealth of expertise in the art of drug discovery and development (including a wide range of disease states and biological targets). His position with Temple University's School of Pharmacy and the Moulder Center for Drug Discovery has provided him with essential experience as an educator and academic scientist. These experiences, as well as his training and expertise as a registered US patent agent, have provided him with the tools and skills necessary to bridge the gap between industrial drug discovery and academic research.