Buch, Englisch, 1600 Seiten, Format (B × H): 219 mm x 276 mm
Buch, Englisch, 1600 Seiten, Format (B × H): 219 mm x 276 mm
ISBN: 978-1-4051-1256-7
Verlag: Wiley
Haematopoietic cell transplantation is the intravenous infusion of haematopoietic progenitor cells designed to establish marrow and immune function in patients with a variety of acquired and inherited malignant and non-malignant disorders. These include hematological malignancies (leukaemia, lymphoma and myeloma), non-malignant acquired bone marrow disorders (aplastic anaemia), and genetic diseases associated with abnormal haematopoiesis and function (thalassaemia, sickle cell anaemia, and severe combined immunodeficiency). Haematopoietic cell transplantation is also key in the support of patients undergoing high-dose chemotherapy for the treatment of malignant diseases for which hematological toxicity would otherwise limit drug administration (e.g. breast, germ-cell and ovarian cancers).
This is an outstanding reference source on bone marrow transplantation which has become recognised as the bible in the field. The original editor, Donnall Thomas, was a pioneer in the field and won the 1990 Nobel Prize for his discoveries concerning organ and cell transplantation in the treatment of human diseases.
During the past three decades there has been outstanding progress in the area which has led to an exponential increase in the number of transplant recipients worldwide. More than 13, 000 new cases of haematopoietic stem cell transplantation per year have been recently reported to the International Bone Marrow Transplant Registry. This considerable increase in number has been paralleled by impressive basic and applied research into the uses of hematopoietic stem cell transplantation. There is therefore now a need for a new edition of Hematopoietic Stem Cell Transplantation to accumulate this knowledge and convey the most current information available.
The third edition will be divided into eight sections containing over 100 chapters written by international experts in the field of blood and bone marrow transplantation. The text will be completely revised and updated throughout to take account of new and recent developments, from both a scientific and clinical perspective. There are ten completely new chapters.
Reviews:
A' must for the bookshelf of any person who has even the vaguest interest in the biology or practice of marrow, blood, or umbilical-cord hematopoietic stem-cell transplantation.'
New England Journal of Medicine
Essential addition to the library of any unit performing bone marrow transplants.'
Journal of Hematotherapy
Uniformly informative, helpful, well-organised and presented, comprehensive, 'up-to-date and well-referenced.'
British Journal of Haematology
Overwhelmingly complete, extremely up-to-date and each chapter is written by a 'world leader in the field.'
Clinical and Laboratory Haematology
Zielgruppe
Clinicians and researchers in the field of blood and bone marrow transplantation, hematologists, transfusion medicine specialists
Autoren/Hrsg.
Weitere Infos & Material
Scientific Basis for Hematopoietic Cell Transplantation
1 A History of Bone Marrow Transplantation, 3
E. Donnall Thomas
2 Uses and Growth of Hematopoietic Cell Transplantation, 9
Mary M. Horowitz
3 Overview of Hematopoietic Cell Transplantation Immunology, 16
Paul J. Martin
4 Histocompatibility, 31
Eric Mickelson - Effie W. Petersdorf
5 Functional Evolution of the Major Histocompatibility Complex, 43
Lakshmi K. Gaur
6 The Hematopoietic Microenvironment, 53
Claudio Brunstein - Catherine M. Verfaillie
7 Molecular Aspects of Stem Cell Renewal, 62
Peter M. Lansdorp
8 Biology of Hematopoietic Stem and Progenitor Cells, 69
Markus G. Manz, Koichi Akashi - Irving L. Weissman
9 Expansion of Hematopoietic Stem Cells, 96
Colleen Delaney, Robert Andrews - Irwin Bernstein
10 Methods for Gene Transfer: Genetic Manipulation of Hematopoietic Stem Cells, 107
Thomas Moritz - David A. Williams
11 Clinical Trials of Gene Marking and Gene Therapy Using Hematopoietic Stem Cells, 118
Donald B. Kohn - Gay M. Crooks
12 Pharmacological Basis for High-Dose Chemotherapy, 130
James H. Doroshow - Timothy Synold
13 Preparative Regimens and Modification of Regimen-Related Toxicities, 158
William I. Bensinger - Ricardo Spielberger
14 Radiotherapeutic Principles of Hematopoietic Cell Transplantation, 178
Brenda Shank - Richard T. Hoppe
15 Radioimmunotherapy and Hematopoietic Cell Transplantation, 198
Dana C. Matthews - Frederick R. Appelbaum
16 Pharmacology and the Use of Immunosuppressive Agents after Hematopoietic Cell Transplantation, 209
Nelson J. Chao
17 T-Cell Depletion to Prevent Graft-vs.-Host Disease, 221
Robert J. Soiffer
18 Documentation of Engraftment and Characterization of Chimerism Following Hematopoietic Cell Transplantation, 234
Eileen Bryant - Paul J. Martin
19 Antibody Mediated Purging, 244
John G. Gribben
20 Pharmacologic Purging of Bone Marrow, 254
O. Michael Colvin
21 Molecular Inhibition of Gene Expression in Hematopoietic Cells, 258
Joanna B. Opalinska - Alan M. Gewirtz
22 The Detection and Significance of Minimal Residual Disease, 272
Jerald P. Radich - Marilyn L. Slovak
23 Pathology of Hematopoietic Cell Transplantation, 286
George E. Sale, Howard M. Shulman - Robert C. Hackman
24 Mechanisms of Tolerance, 300
Megan Sykes
25 The Experimental Basis for Hematopoietic Cell Transplantation for Autoimmune Diseases, 324
Judith A. Shizuru
26 Murine Models for Graft-vs.-Host Disease, 344
Robert Korngold - Thea M. Friedman
27 The Pathophysiology of Graft-vs.-Host Disease, 353
James L.M. Ferrara - Joseph Antin
28 Graft-versus-Tumor Responses, 369
Alexander Fefer
29 Adoptive Immunotherapy with Antigen-Specific T Cells, 380
Stanley R. Riddell - Philip D. Greenberg
30 Autologous Graft-vs.-Host Disease, 405
Allan D. Hess - Richard J. Jones
31 Biostatistical Methods in Hematopoietic Cell Transplantation, 414
Joyce C. Niland
32 Outcomes Research in Hematopoietic Cell Transplantation, 434
Stephanie J. Lee
Patient-Related Issues in Hematopoietic Cell Transplantation
33 The Evaluation and Counseling of Candidates for Hematopoietic Cell Transplantation, 449
Karl G. Blume - Michael D. Amylon
34 Clinical and Administrative Support for Hematopoietic Cell Transplant Programs, 463
Laura L. Adams - Angela A. Johns
35 Nursing Issues in Hematopoietic Cell Transplantation, 469
Rosemary C. Ford, Judy Campbell - Juanita Madison
36 The Patients Perspective, 483
Susan K. Stewart
37 Ethical Issues in Hematopoietic Cell Transplantation, 488
David S. Snyder
38 Psychosocial Issues in Hematopoietic Cell Transplantation, 497
Michael A. Andrykowski - Richard P. McQuellon
39 Assessment of Quality of Life in Hematopoietic Cell Transplantation Recipients,507
Karen Syrjala
40 Sexuality after Hematopoietic Cell Transplantation, 519
D. Kathryn Tierney
Sources of Hematopoietic Cells for Human Transplant
41 Hematopoieti
