Buch, Englisch, 272 Seiten, Format (B × H): 156 mm x 237 mm, Gewicht: 558 g
ISBN: 978-0-470-02137-8
Verlag: Wiley
This title provides an extremely helpful analysis of genes that may be associated with autoimmunity, and answers questions such as how these genes can be identified, and how the functions of the gene products can be elucidated.
Incorporating data on disease-associated chromosomal loci that has been accumulated from inbred mice, the title:
- descibes how some susceptibility loci may be common to many diseases, whereas others are relatively disease specific
- discusses the importance of developing criteria for establishing the significance of these different categories of disease-associated loci.
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
Symposium on Genetics of autoimmunity, held at the Novartis Foundation, London, 22-24 June 2004
Editors: Gregory Bock (Organizer) and Jamie Goode
This symposium is based on a proposal by AbulK. Abbas, David A. Hafler and John D. Rioux
Abul Abbas
Chair's introduction 1
MarkJ. Daly
Patterns of genetic variation in humans and mice 2
Discussion 8
David B. Goldstein
Haplotype tagging in pharmacogenetics 14
Discussion 19
Simon J. Foote, Justin P. Rubio, Melanie Bahlo, Trevor J. Kilpatrick, Terence P. Speed, Jim Stankovich, Rachel Burfoot, Helmut Butzkueven, Laura Johnson, Chris Wilkinson, Bruce Taylor, Michele Sale, Ingrid A. F. van der Mei, Joanne L. Dickinson and Patricia Groom
Multiple sclerosis: a haplotype association study 31
Discussion 39
Juha Kere
Mapping genes for asthma and psoriasis 46
Discussion 52
Linda S. Wicker, Carolyn L. Moule, Heather Fraser, Carlos Penha-Goncalves, Dan Rainbow, Valerie E. S. Garner, Giselle Chamberlain, Kara Hunter, Sarah Howlett, Jan Clark, Andrea Gonzalez-Munoz, Anne-Marie Cumiskey, Paul Tiffen, Joanna Howson, Barry Healy, Luc J. Smink, Amanda Kingsnorth, Paul A. Lyons, Simon Gregory, Jane Rogers, John A. Todd and Laurence B. Peterson
Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse 57
Discussion 65
Srividya Subramanian and Edward K. Wakeland
The importance of epistatic interactions in the development of autoimmunity 76
Discussion 88
Timothy J. Vyse, Angela M. Richardson, Emily Walsh, Lisa Farwell, Mark J. Daly, Cox Terhorst and John D. Rioux
Mapping autoimmune disease genes in humans: lessons from IBD and SLE 94
Discussion 107
Martin C. Wapenaar and Cisca Wijmenga
A combined genetics and genomics approach to unravelling molecular pathways in coeliac disease 113
Discussion 134
Timothy W. Behrens, Robert R. Graham, Chieko Kyogoku, Emily C. Baechler, Paula S. Ramos, Clarence Gillett, Jason Bauer, Ward A. Ortmann, Keli L. Hippen, Erik Peterson, Carl D. Langefeld, Kathy L.Moser, Patrick M. Gaffney and Peter K. Gregersen
Progress towards understanding the genetic pathogenesis of systemic lupus erythematosus 145
Discussion 160
Vigo Heissmeyer, Fernando Macian, Rajat Varma, Sin-Hyeog Im, Franciscia Garcia-Cozar, Heidi F. Horton, Michael C. Byrne, Stefan Feske, K. Venuprasad, Hua Gu, Yun-Cai Liu, Michael L. Dustin and Anjana Rao
A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signalling 165
Discussion 174
Adrian Liston and Christopher C. Goodnow
Genetic lesions in thymic T cell clonal deletion and thresholds for autoimmunity 180
Discussion 192
Lalitha Vijayakrishnan, Jacqueline M. Slavik, Zsolt Illes, Dan Rainbow, Laurence B. Peterson, Arlene S. Sharpe, Linda S. Wicker and Vijay K. Kuchroo
An autoimmune disease-associated CTLA4 splice variant lacking the B7 binding domain signals negatively in T cells 200
Discussion 212
Adrian Ting, Stefan Lichtenthaler, Ramnik Xavier, Soon-Young Na, Shahrooz Rabizadeh, Tara Holmes and Brian Seed
Large-scale screens for cDNAs with in vivo activity 219
Discussion 229
Jenny Ting
Genomic mining of new genes and pathways in innate and adaptive immunity 231
Discussion 239
Index of contributors 242
Subject index 244
