Homeostatic Control of Brain Function

Erscheinungsjahr 2015
ISBN: 978-0-19-932229-9
Verlag: OXFORD UNIV PR

Buch, Englisch, 658 Seiten, Format (B × H): 183 mm x 260 mm, Gewicht: 1413 g

Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders.

Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health.

Key Features include
· A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks.
· Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise.
· Incorporation of homeostatic therapies into existing basic and clinical research paradigms.
· Extensive scientific basic and clinical research ranging from molecules to disorders.

· Emerging practical information for improving homeostasis.
· Examples of homeostatic therapies in preventing and delaying dysfunction.

Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.

Autoren/Hrsg.

Boison, Detlev

Masino, Susan A.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Psychiatrie, Sozialpsychiatrie, Suchttherapie
• Naturwissenschaften Biowissenschaften Biowissenschaften Neurobiologie, Verhaltensbiologie

Inhaltsverzeichnis

- Prologue

- Part I: Homeostatic Regulators: Molecules and Ions

- Chapter 1: Microdynamics of water and ion homeostasis in the brain: role of aquaporins and ion channels of astroglial cells

- Chapter 2: Homeostatic control of adenosine levels and functions in brain

- Chapter 3: Glutamate homeostasis as a regulatory of neurotransmitter recycling and synaptic function)

- Chapter 4: Homeostasis of neuronal excitability via synaptic and intrinsic inhibitory mechanisms

- Part II: Homeostatic Control: Systems, Cells and Organelles

- Chapter 5: Role of astrocytes in sleep and epilepsy

- Chapter 6: Neuron-astrocyte interactions

- Chapter 7: Homeostatic synaptic scaling at central synapses

- Chapter 8: Homeostatic role of heterosynaptic plasticity

- Chapter 9: The Blood Brain Barrier

- Chapter 10: Inflammation and immunomodulation in epilepsy and its comorbidities

- Chapter 11: Neuroplasticity

- Chapter 12: Epigenetics

- Chapter 13: Adult neural stem cells and brain homeostasis

- Part III: Homeostatic Manipulators: Preventative and Restorative Opportunities

- Chapter 14: Systems (network) pharmacology for brain functionality restoration

- Chapter 15: Ketogenic diets, mitochondria, and neurological diseases

- Chapter 16: Dietary manipulations

- Chapter 17: Exercise

- Chapter 18: Sleep

- Chapter 19: Botanicals

- Chapter 20: The role of acupuncture in nociception homeostasis

- Chapter 21: Meditation

- Chapter 22: Neurotrophic regulation in neurorestoration of brain

- Part IV: Homeostatic Therapies for Disease and Dysfunction

- Chapter 23: Epilepsy

- Chapter 24: Traumatic Brain Injury

- Chapter 25: Adenosine and Alzheimer's Disease, a possible epigenetic link

- Chapter 26: Brain homeostasis and Parkinson's Disease

- Chapter 27: Brain homeostasis and addiction

- Chapter 28: Anxiety and stress disorders

- Chapter 29: Malignant brain cancer management with metabolic therapy

- Chapter 30: Obesity and diabetes: Nature, nurture, and beyond

- Chapter 31: Autism spectrum disorders and homeostasis

Über Autor(innen)

Detlev Boison is the Robert Stone Dow Chair of Neurology; the Director of Neurobiology Research; and the Director of Basic and Translational Research at the Legacy Research Institute

Susan A. Masino is the Vernon Roosa Professor of Applied Science; and a Professor of Neuroscience and Psychology at Trinity College