BetaSys

Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells
1. Auflage 2011
ISBN: 978-1-4419-6955-2
Verlag: Springer

Buch, Englisch, 556 Seiten, Book w. online files / update, Format (B × H): 160 mm x 241 mm, Gewicht: 1021 g

Reihe: Systems Biology

BetaSys uses the example of regulated exocytosis in pancreatic ß-cells, and its relevance to diabetes, to illustrate the major concepts of systems biology, its methods and applications.

Zielgruppe

Research

Autoren/Hrsg.

Booß-Bavnbek, Bernhelm

Klösgen, Beate

Larsen, Jesper

Pociot, Flemming

Renström, Erik

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
• Mathematik | Informatik EDV | Informatik Angewandte Informatik Bioinformatik

Inhaltsverzeichnis

Preface.- Systems biology of ß-cells - revisited.- Established facts and open questions of the focused systems analysis of regulated exocytosis in ß-cells – a background for a focused systems analysis approach.- Mitochondria and metabolic signals in ß-cells.- ß-cell ontogenesis and the insulin production apparatus.- The role of the cytoskeleton in transport and release of the insulin-containing granules by pancreatic ß-cells.- The mathematical microscope making the inaccessible accessible.- Magnetic resonance imaging of pancreatic ß-cells.- Mapping the ß-cell in 3D at the nanoscale using novel cellular electron tomography and computational approaches.- In vivo applications of inorganic nanoparticles.- Cell cultivation and sensor-based assays for dynamic measurements of cell vitality: basic concepts.- Bioimpedance spectroscopy.- DNA variations, impaired insulin secretion and type-2 diabetes.- Genetically programmed defects in ß-cell function.- Proteomic analysis of the pancreatic islet ß-cell secretory granule: current understanding and future opportunities.- Physiological and pathophysiological role of islet amyloid polypeptide (IAPP, amylin) - a role in the pathogenesis of type-2 diabetes.- Present state of islet transplantation for type-1 diabetes patients.- Predictive protein networks and identification of drugable targets in the ß-cell.- Nanotoxicity.- From silicon cell to silicon human.- Probing cellular dynamics with mesoscopic simulations.- What drives calcium oscillations in ß-cells? new tasks for cyclic analysis.- Whole-body and cellular models of glucose-stimulated insulin secretion.- Geometric and electromagnetic aspects of fusion pore making.- Index.