Buch, Englisch, Band 56, 242 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 541 g
Stem Cells and Precursors
Buch, Englisch, Band 56, 242 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 541 g
Reihe: Results and Problems in Cell Differentiation
ISBN: 978-3-662-44607-2
Verlag: Springer
With an eye to the human patient, encouraging results have been generated that identify parallels between embryonic myogenesis and regenerating myofibers due to common regulatory molecules. On the other hand, both processes differ considerably in quality and complexity of the processes employed. Interestingly, the heterogeneity in embryonic sources from which skeletal muscle groups in the vertebrate including the human body take origin is paralleled by differences in their susceptibility to particular muscle dystrophies as well as by the characteristics of the satellite cells involved in regeneration. The progress that has been made in the field of muscle stem cell biology, with special focus on the satellite cells, is outlined in this book by experts in the field. The authors review recent insights of the heterogeneous nature of these satellite cells regarding their gene signatures and regeneration potential. Furthermore, an improved understanding of muscle stem cells seems only possible when we study the impact of the cell environment on efficient stem cell replacement therapies for muscular dystrophies, putting embryological findings from different vertebrate classes and stem cell approaches into context.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
Recruitment of skeletal muscle progenitors to secondary sites: A role for CXCR4/SDF-1 signaling in skeletal muscle development.- Hypaxial muscle - controversial classification and controversial data? Skeletal Myogenesis in the Zebrafish and its Implications for Muscle Disease Modeling.- Mechanisms of Myogenic Specification and Patterning.- The avian embryo as a model system for skeletal myogenesis.- Head Muscle Development.- The lateral plate mesoderm – a novel source of skeletal muscle.- Regulation of skeletal muscle development and disease by microRNAs.- Adult skeletal muscle stem cells.- Dormancy and quiescence of skeletal muscle stem cells.