Introduction to Enzyme and Coenzyme Chemistry

4. Auflage 2026
ISBN: 978-1-394-36559-3
Verlag: John Wiley & Sons Inc

Buch, Englisch, 352 Seiten, Format (B × H): 172 mm x 244 mm, Gewicht: 674 g

A comprehensive, up-to-date discussion of what enzymes are, how they work, and how they catalyse enzymatic reactions

Enzymes are giant macromolecules which catalyse all the biochemical reactions in living cells. Their three-dimensional structures are highly complex, yet they are formed by spontaneous folding of a linear polypeptide chain. Their catalytic properties are even more impressive than synthetic catalysts which operate under more extreme conditions. Enzyme-catalysed reactions proceed very high enantioselectivity and enantiospecificity at rates which approach “catalytic perfection.” Living cells carry out a huge repertoire of enzyme-catalysed chemical reactions, some of which have little or no precedent in organic chemistry.

The popular textbook Introduction to Enzyme and Coenzyme Chemistry has been thoroughly updated with information on the most recent advances in our understanding of enzyme action. This newly revised fourth edition includes: - New case studies

- A new section on oxygen activation by enzymes
- Expanded sections on membrane proteins, enzyme purification, enzymatic phosphoryl transfer reactions, fatty acid biosynthesis and polyketide biosynthesis

- Additional examples from recent literature used to illustrate key points
- Additional problems and solutions outlined and updated Further Reading sections at the end of each chapter

- Over 40 full-colour figures of the active sites of enzymes that illustrate the interplay between enzyme structure and function

Introduction to Enzyme and Coenzyme Chemistry provides a concise but comprehensive account from the perspective of organic chemistry that explains what enzymes are, how they work, and how they catalyse many of the major classes of enzymatic reactions. It will prove invaluable to undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry, chemical biology, biochemistry and biotechnology.

Autoren/Hrsg.

Bugg, T. D. H.

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie Biochemie
• Naturwissenschaften Biowissenschaften Proteinforschung
• Naturwissenschaften Biowissenschaften Enzymologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)

Inhaltsverzeichnis

Biography vii

Preface to 4th Edition ix

Representation of Protein Three-Dimensional Structures xi

Chapter 1 From Jack Beans to Designer Genes 1

Chapter 2 All Enzymes Are Proteins 9

Chapter 3 Enzymes Are Wonderful Catalysts 29

Chapter 4 Methods for Studying Enzymatic Reactions 55

Chapter 5 Hydrolytic and Group Transfer Enzymes 85

Chapter 6 Enzymatic Redox Chemistry 129

Chapter 7 Enzymatic Carbon–Carbon Bond Formation 169

Chapter 8 Enzymatic Addition/Elimination Reactions 209

Chapter 9 Enzymatic Transformations of Amino Acids 227

Chapter 10 Isomerases 245

Chapter 11 Radicals in Enzyme Catalysis 261

Chapter 12 Non-Enzymatic Biological Catalysis 283

Appendix 1: Cahn-Ingold-Prelog Rule for Stereochemical Nomenclature 303

Appendix 2: Amino Acid Abbreviations 305

Appendix 3: A Simple Demonstration of Enzyme Catalysis 307

Appendix 4: Answers to Problems 309

Index 319

Über Autor(innen)

Timothy D. H. Bugg is Professor of Biological Chemistry at the University of Warwick. His academic career started at the University of Southampton in 1991, where his group studied enzymes involved in the bacterial degradation of aromatic compounds and enzymes involved in bacterial peptidoglycan assembly. Since moving to Warwick in 1999, his group has more recently studied enzymes involved in bacterial degradation of lignin, and the application of biocatalysis to convert lignin into renewable aromatic chemicals.