Structural Biology of Ubiquitination

From Mechanisms to Interventions
Erscheinungsjahr 2026
ISBN: 978-0-443-44974-1
Verlag: Elsevier Science Publishing Co Inc

Buch, Englisch, 350 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 450 g

Structural Biology of Ubiquitination: From Mechanisms to Interventions provides an in-depth exploration of the structural and biophysical principles governing ubiquitination and their implications in diseases such as cancer and neurodegeneration. The book seamlessly integrates experimental insights with advanced computational methods, including AI-driven drug discovery, molecular modeling, and biophysical simulations, offering a comprehensive toolkit for researchers and clinicians. By bridging fundamental science with translational applications, the book empowers readers to design targeted therapeutics, understand disease mechanisms at the molecular level, and accelerate progress toward personalized medicine.

Autoren/Hrsg.

Chaturvedi, Navaneet

Kumar, Vijay

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Physik Angewandte Physik Biophysik
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)

Inhaltsverzeichnis

1. Introduction to Ubiquitination: Mechanisms, enzymes (E1, E2, E3), and biological significance
2. Structural level of Ubiquitination through the eyes of Cryo-EM, X-ray crystallography, and NMR
3. Structural biology of Ubiquitin ligases
4. Computational Biophysics in Ubiquitination Studies
5. Dysregulation of Ubiquitination in Cancer: Molecular mechanisms and oncogenic pathways
6. Deubiquitinases (DUBs) as Cancer Regulators: Structural and Computational Insights for targeted therapy
7. Dysregulation of Ubiquitination in Neurodegeneration: Molecular mechanisms and neurodegenerative pathways
8. Deubiquitinases (DUBs) in Amyotrophic Lateral Sclerosis (ALS): Mechanisms and therapeutic interventions
9. AI and Machine Learning in Ubiquitination and Drug Discovery
10. PROTACs and Targeted Protein Degradation Strategies in Ubiquitination-linked Disease Therapy
11. Challenges and Future Perspectives in Ubiquitination Research
12. Translational Research and Clinical Trials in Ubiquitination-Targeted Therapy

Über Autor(innen)

Chaturvedi, Navaneet
Navaneet Chaturvedi is an assistant professor at the Amity Institute of Biotechnology, Amity University, Noida, India. He has built a solid foundation and essential skills for a research-intensive role. With extensive experience, Dr. Chaturvedi is eager to contribute to the vibrant research community. His work spans institutions worldwide, including Tel Aviv University, IIT BHU, University of Information Science & Tech North Macedonia, University of Leicester, and PharmCADD in South Korea, enabling collaboration with multidisciplinary teams and fostering innovation. His expertise includes molecular dynamics simulation, molecular docking, free energy calculations, machine learning, protein folding, and computer-aided drug design. Dr. Chaturvedi has a growing portfolio of research and review articles and book chapters published in leading international journals and publishers.

Kumar, Vijay
Vijay Kumar, PhD, is an assistant professor at Amity University. He earned his PhD in Biophysics from AIIMS, New Delhi, and completed a postdoctoral fellowship at UMass Medical School, focusing on folding and aggregation of proteins such as SOD1 and TDP-43 implicated in motor neuron disease, ALS, and FTD. Returning to India, he served as Principal Investigator under the DST-SERB Young Scientist Scheme at Jamia Millia Islamia. His current research centers on protein folding, misfolding, and aggregation, and the role of toxic RNA species in neurodegenerative diseases. He is a member of the Protein Society, Indian Biophysical Society, Indian Academy of Neurosciences, and the International Society for Neurochemistry. He has held fellowships from CSIR and a DAAD fellowship in Germany.