Lessons in Bioreactor Scale-Up

1. Auflage 2026
ISBN: 978-1-041-41125-3
Verlag: Taylor & Francis

Buch, Englisch, 130 Seiten, Format (B × H): 138 mm x 216 mm, Gewicht: 400 g

Reihe: Emerging Technologies in Biomanufacturing

Bioreactor scale-up in pharmaceutical science refers to the process of transferring optimal conditions obtained in small-scale, often high-throughput, bioreactors to large-scale bioreactors. It involves considerations such as mass and heat transfer phenomena, tech transfer, and defining and validating operating conditions. The goal is to ensure product quality and facilitate seamless scale conversion. Cell culture bioreactor scale-up is a critical step in the production of biologics such as therapeutic proteins, monoclonal antibodies, and vaccines that are administered to patients suffering from various diseases. It involves translating laboratory discoveries to large-scale industrial applications, while maintaining product quality and cost-effectiveness. Bioreactor scale-up in bioprocessing industry involves transitioning from miniaturized, high-throughput bioreactors to larger bench-scale, pilot- or production-scale bioreactors. It is a pivotal aspect of modern biotechnology, allowing lab discoveries to be developed and applied industrially.

- Bioreactor scale-up is a critical step in the production of biologics such as therapeutic proteins, monoclonal antibodies, and vaccines.

- This valuable process involves translating laboratory discoveries to large-scale industrial applications, while maintaining product quality and cost-effectiveness.

- Bioreactor scale-up in chemistry involves transitioning from miniaturized, high-throughput bioreactors to larger bench-scale and pilot- or production-scale bioreactors.

- A pivotal aspect of modern biotechnology is allowing lab discoveries to be applied industrially.

- Bioreactor scale-up sustainability involves improving fermentation production processes and bioreactor technology to reduce costs, create compelling products, and scale the industry.

- Geometric similarity in bioreactors is crucial for successful scaling-up.

Zielgruppe

Academic, Postgraduate, Professional Practice & Development, Professional Reference, and Professional Training

Autoren/Hrsg.

Chaudhry, Muhammad Arshad

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Verfahrenstechnik, Chemieingenieurwesen
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)

Inhaltsverzeichnis

Chapter 1: Exploring Introductory Principles. Chapter 2: A Refresher on Fluid Flow and Mixing. Chapter 3: Experimental Determination and Application of Oxygen Mass-Transfer Rate, Mass-Transfer Coefficient, and Oxygen-Uptake Rate. Chapter 4: Physiochemical Factors Affecting Oxygen Transfer and the Volumetric Mass-Transfer Coefficient in Stirred Tanks. Chapter 5: Theoretical and Empirical Correlations for Predicting the Mass-Transfer Coefficient in Stirred-Tank Bioreactors. Chapter 6: Dissolved Carbon Dioxide and Its Impact on Cell-Culture Systems. Chapter 7: Insights into Dissolved Carbon Dioxide (dCO2) Accumulation in Cell-Culture Bioreactors. Chapter 8: Strategies To Control dCO2 Accumulation Using Aeration Flow Rate. Chapter 9: Use of Mathematical Models To Design dCO2 Stripping Strategies

Über Autor(innen)

Muhammad “Arshad” Chaudhry is working as Director – Cell Line and Upstream Process Development at Disc Medicine for the past one year. Prior to that, he has worked in various roles in upstream processing, covering a wide range of biologics (monoclonal antibodies, fusion proteins, allogeneic cell therapy, lenti and AAV-based viral vectors, etc.). He has been in the cell culture field for almost 20 years now and has worked mostly in the upstream process development supporting both early and late-stage projects covering CMC activities, GMP manufacturing of clinical-grade material, QbD-based scale-down model development, and process characterization studies. He holds a Ph.D. in Biochemical Engineering from University of British Columbia, Vancouver Canada having worked under Dr. James Piret’s guidance on embryonic stem cell bioengineering and fed-batch process development projects.