Molecular Genetic Pathology

2. Auflage 2013
ISBN: 978-1-4614-4801-3
Verlag: Springer

Buch, Englisch, 1136 Seiten, Book + Online Access, Format (B × H): 178 mm x 254 mm

Molecular Genetic Pathology, Second Edition presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Fully updated in each area and expanded to include identification of new infectious agents (H1N1), new diagnostic biomarkers and biomarkers for targeted cancer therapy. This edition is also expanded to include the many new technologies that have become available in the past few years such as microarray (AmpliChip) and high throughput deep sequencing, which will certainly change the clinical practice of molecular genetic pathology. Part I examines the clinical aspects of molecular biology and technology, genomics. Poharmacogenomics and proteomics, while Part II covers the clinically relevant information of medical genetics, hematology, transfusion medicine, oncology, and forensic pathology. Supplemented with many useful figures and presented in a helpful bullet-point format, Molecular Genetic Pathology, Second Edition provides a unique reference for practicing pathologists, oncologists, internists, and medical genetisists.  Furthermore, a book with concise overview of the field and highlights of clinical applications will certainly help those trainees, including pathology residents, genetics residents, molecular pathology fellows, internists, hematology/oncology fellows, and medical technologists in preparing for their board examination/certification.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Cheng, Liang

Zhang, David Y.

Eble, John N.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pathologie, Cytopathologie, Histopathologie

Inhaltsverzeichnis

Part I General Sections  Section I:  Basic Principles1 Principles of Clinical Molecular Biology  Shaobo Zhang, MD, Darrell D. Davidson, MD, PhD, and Liang Cheng, MD2 Principles of Clinical Cytogenetics Stuart Schwartz, PhD, FACMG3 Conceptual Evolution in Cancer Biology  Shaobo Zhang, MD, Darrell D. Davidson, MD, PhD, Rodolfo Montironi, MD, Antonio Lopez-Beltran, MD, Gregory T. MacLennan,  and Liang Cheng, MD4 Genetic Inheritance and Population Genetics  Tatiana Foroud, PhD,  and Daniel L. Koller, PhD5 Clonality Analysis and Tumor of Unknown Primary: Applications in Modern Oncology and Surgical Pathology Liang Cheng, MD, Shaobo Zhang, MD, Federico A. Monzon, MD,  Timothy D. Jones, MD6 Modern Immunohistochemistry in Targeted Therapy Allen M. Gown7 Systems Pathology Jose Costa, MD and Michael Donovan, MD Section II:  Methodology8 Diagnostic Methodology and Technology Josephine Wu MD, Fei Ye MD, Miao Cui MD, Robert Shibata MD, Ruliang Xu MD, Liang Cheng MD, David Y. Zhang MD9 Clinical Flow Cytometry  Magdalena Czader, MD, PhD10 Clinical Genomics in Oncology Hugo M. Horlings, MD, PhD Thalia Farazi, MD, PhD and  Marc van de Vijver, MD, PhD11 Clinical Proteomics David H. Geho, MD, PhD, Virginia Espina, MS, Lance A. Liotta, MD, PhD, Emanuel F. Petricoin, PhD, and Julia D. Wulfkuhle, PhD12 Nanotechnology in Molecular Diagnostics Andrew N Young MD PhD and Brad A Kairdolf PhD13 Gene Therapy: Vector Technology and Clinical Applications Sunyong Tang, PhD and Kenneth Cornetta, MD14 Instrumentation for Molecular Testing Jordan Laser MD, Miao Cui MD, Bruce E. Petersen MD, Fei Ye MD, David Y. Zhang MD15 Tissue Microarrays and Biomarker Validation  Martina Storz, BS and Holger Moch, MD16 Laser Capture Microdissection  Liang Cheng MD, Shaobo Zhang MD, Darrell D. Davidson MD,  Matthew Kuhar MD, Mingsheng Wang MD, David Y. Zhang MD, Gregory T. MacLennan MD17 Human Tissue Biorepository William E. Grizzle, Katherine C. Sexton, Walter C. Bell18 Pathology Informatics  Roy E Lee MD, Long P Le MD PhD, John R Gilbertson MD Part II. Clinical Application and Disease-Based Sections  Section III:  Genetic Disorders19 Prenatal Cytogenetic and Cytogenomic Diagnosis Ninette Cohen, PhD and Lisa Edelmann, PhD20 Molecular Medical Genetics Lisa Edelmann, PhD, Stuart A. Scott, PhD, Liu Liu, PhD,  Ruth Kornreich, PhD21 Biochemical Genetics and Inborn Errors of Metabolism Chunli Yu, MD, Melissa Wasserstein, MD, George Diaz, MD, PhD22 Molecular Genetics of Congenital Heart Disease Abigail E Southard, BA and Bruce D Gelb, MD23 Familial Cancer Syndromes Beth Harrison, MD, Rodolfo Montironi, MD, Antonio Lopez-Beltran, MD, Michelle P. Elieff, MD, Liang Cheng, MD24 Genetic Counseling  Kimberly A Quaid, PhD and Lisa J Cushman, PhD  Section IV:  Molecular Microbiology 25 Molecular Virology Fei Ye MD, Miao Cui MD, Rame Khasawneh MD, Robert Shibata MD, Josephine Wu MD, Mona Sharaan MD, David Y. Zhang MD26 Molecular Bacteriology and Mycobacteriology Jeong Hwan Shin, MD, PhD, Mona Sharaan, MD, Josephine Wu, DDS, CLSP(MB), CLDIR, Miao Cui, MD, David Y. Zhang, MD, PhD, MPH, Yi-Wei Tang, MD, PhD27 Molecular Parasitology and Mycology Vincent J LaBombardi, PhD, Wei Wang, PhD28 Molecular Microbiology in Transplantation Adnan A Alatoom, MD and Robin Patel, MD29 Molecular Microbiology Epidemiology Miao Cui MD, Fei Ye MD, David Y. Zhang MD  Section V: Hematologic Malignancies30 Principle of Immunoglobulin and T Cell Receptor Gene Rearrangement Jeffrey E. Miller, PhD31 Molecular Diagnostics of Lymphoblastic Leukemia and Lymphoma Zeqiu J Han, MD and Dan Jones, MD, PhD32 Molecular Diagnostics of Myeloid Neoplasms C Cameron Yin, MD, PhD and Dan Jones, MD, PhD33 Molecular Diagnostics of Lymphoid Malignancies Vasiliki Leventaki, MD and Francisco Vega, MD, PhD34 Molecular Diagnostics of Myeloproliferative Neoplasms and Myelodysplastic Syndromes Gerlinde Wernig, MD, and Daniel A. Arber, MD35 Molecular Diagnostics of Lymphoproliferative Disorders Timothy C. Greiner, MD  Section VI: Hematological Disorders and Specialized Applications36 Molecular Testing for Coagulation Abnormalities Veshana Ramiah, MD and Thomas L. Ortel, MD, PhD37 Molecular Hemoglobinopathies Tina Y. Fodrie, BS, MT, MP (ASCP), Shaobo Zhang, MD, Minaxiben Patel, MT, MP (ASCP), Jodi A. Parks, MD, and Liang Cheng, MD38 The HLA System and Transfusion Medicine: Molecular Approach S Yoon Choo, MD39 Clinical Pharmacogenomics  Catalina Lopez-Correa, MD, PhD and Lawrence M. Gelbert, PhD40 Molecular Forensic Pathology Stephen R. Dlouhy, PhD and P. Michael Conneally, PhD41 Specimen Identification and Bone Marrow Engraftment Analysis Loren J Joseph, MD42 Circulating Tumor Cells: The Liquid Biopsy for Molecular Pathology Jeffrey S. Ross, MD Section VII:  Laboratory Management43 Ethical and Legal Issues in Molecular Testing  Kimberly A. Quaid, PhD44 Regulatory Issues in Molecular Testing Frank S. Ong MD, Wayne W. Grody MD PhD, Kingshuk Das, MD45 Molecular Pathology Reporting Stacey S. O’Neill MD PhD and Margaret L. Gulley MD46 Quality Assurance and Laboratory Inspection Kristin M. Post, MT(ASCP) and Liang Cheng, MD

Über Autor(innen)

Liang Cheng, M.D. Indiana University School of Medicine, Indianapolis, IN, USADavid Zhang, M.D. Mount Sinai School of Medicine, New York, NY, USA John N. Eble, M.D.Indiana University School of Medicine, Indianapolis, IN, USA