Microbiota Brain Axis

A Neuroscience Primer
Erscheinungsjahr 2024
ISBN: 978-0-12-814800-6
Verlag: Elsevier Science Publishing Co Inc

Buch, Englisch, 496 Seiten, Format (B × H): 227 mm x 151 mm, Gewicht: 454 g

Microbiota Brain Axis: A Neuroscience Primer provides neuroscience researchers with a comprehensive guide on how to conduct effective microbiota-brain research, understand the appropriate methodologies, and collect and analyze microbiota data. The book begins with an introduction to the importance of the microbiota-brain communication in development and how microbiota impact neurodevelopmental disorders, mental health and neurodegeneration. In addition, the book discusses advances in microbiota analysis tools and techniques for neuroscience related research.

Zielgruppe

Advanced students, basic researchers, and clinical researchers in behavioral neuroscience, neuroimmunology, biological psychiatry, developmental neuroscience, and related fields; researchers in physiology, nutrition, immunology, and gastroenterology

Autoren/Hrsg.

Clarke, Gerard

Foster, Jane

Fachgebiete

• Sozialwissenschaften Psychologie Allgemeine Psychologie Biologische Psychologie, Neuropsychologie

Inhaltsverzeichnis

1. The gut-brain axis
2. What is a healthy microbiome?
3. Gene-environment factors influence microbiota composition, diversity, and function
4. Microbiota to brain communication
5. Microbiota influence behaviour - work in animal models
6. Microbiota influence brain systems - work in animal models
7. Microbiota in neurodevelopmental disorders
8. Microbiota in psychiatry
9. Microbiota-brain interactions in aging and neurodegeneration
10. Pharmacological treatments and the microbiome - Antibiotics and nonantibiotic drugs
11. Microbial-related treatments
12. Microbiota-related biomarkers for precision medicine and drug discovery

Über Autor(innen)

Clarke, Gerard
Prof. Gerard Clarke, Ph.D., is a Professor of Neurobehavioral Science in
the Department of Psychiatry and Neurobehavioral Science and a Principal
Investigator in APC Microbiome Ireland at University College Cork. His
research program includes a focus on translational biomarkers of stress-related
neuropsychiatric disorders, the impact of the gut microbiome on
brain and behavior across the life span, and microbial regulation of tryptophan
metabolism. Key achievements of his lab in the generation of
knowledge around the microbiota - gut - brain axis include the demonstration
that the gut microbiome regulates the hippocampal serotonergic
system in a sex-dependent manner, findings that paved the way for
numerous lines of inquiry on the effects of the gut microbiome on neurodevelopment,
brain function, and behavior. He is regularly included in
Clarivate Analytics Highly Cited Researchers list, placing him among the
world's top one percent of researchers by citation. His current approach is
based on advancing frontier knowledge in microbiome research to yield
potential new therapeutic targets for the effective treatment of the central
nervous system and gastrointestinal disorders.

Foster, Jane
Dr. Jane Foster, Ph.D., is a Professor in the Department of Psychiatry, at the Center for Depression Research and Clinical Care at UT Southwestern Medical Center in Dallas, Texas. In the past 20 years, Dr. Foster has developed an internationally recognized translational research program that uses a 'bench to bedside' and back again approach to studying microbiota - brain and immune - brain systems. As one of the early proponents of the role of gut - brain axis in mental health, her lab produced important data demonstrating a role for the microbiome in brain development and behavior in animal studies and recently has extended this work to study the complex neurobiological underpinnings of microbiota - brain and neuroimmune systems in psychiatric illness in clinical populations. Her multidisciplinary expertise includes behavioral neuroscience, molecular biology, immunology, neuroimaging, microbiome, and bioinformatics in both preclinical and clinical research domains. Dr. Foster's research program has developed high-quality analytical pipelines for biological data and novel analytical tools for integrating data across modalities.