Cohen | Pharmacogenomics and Personalized Medicine | Buch |

Cohen Pharmacogenomics and Personalized Medicine

2008, 509 Seiten, Gebunden, Book, Format (B × H): 155 mm x 235 mm, Gewicht: 995 g Reihe: Methods in Pharmacology and Toxicology
ISBN: 978-1-934115-04-6
Verlag: Springer, Berlin

Cohen Pharmacogenomics and Personalized Medicine

concerns within the pharmaceutical industry about generating data that might be difficult to interpret in a regulated environment. There is also a growing apprec- tion for the challenges in translating this new information into clinical utility, including scientific, commercial, ethical, and policy challenges. Pharmacogenomics and Personalized Medicine, which is part of the Methods in Pharmacology and Toxicology series, comprises chapters on selected aspects of pharmacogenomics and personalized medicine. Our overall intent is to assist both novice and experienced investigators in understanding the current scientific ch- lenges in applying PGx to discovery and clinical development and in making app- priate decisions to engage in and interpret PGx research. Designed to share the experiences of leading experts in the field, the book is a useful guide for conducting PGx research--from discovery to the market, but we also aim to present a realistic perspective on the challenges, practicalities, and obstacles in applying pharmac- enomics. Generally, the book avoids statements such as “Pharmacogenomics is going to revolutionize the practice of medicine,” which are neither realistic nor particularly useful to anyone. The book presents an industry perspective on the implementation of PGx in research and development, in drug discovery, and in clinical trials, including rec- mendations for a systematic approach for assessing the feasibility and added value of PGx studies in clinical trials.




Weitere Infos & Material

Preface Contributors Challenges, Opportunities and Evolving Landscape in Pharmacogenomicsand Personalized Medicine: An Industry PerspectiveNadine Cohen and Theresa Frangiosa Considerations for Sample Collections Intended for Pharmacogenomic analyses: The Pharmacogenomics protocol and informed consent formDeborah Ricci and Monique Franc Pharmacogenomics: The Regulatory Environment and Labeling ImplicationMyong-Jin Kim, Shiew-Mei Huang, Atiqur Rahman, Felix W. Frueh,Lawrence J. Lesko Applications of Pharmacogenomics in Drug DiscoveryDuncan McHale Applications of Pharmacogenomics in Clinical TrialsMonique Franc Pharmacogenomics applications in drug metabolism: from genotyping to druglabel-challenges?Ann K. Daly The Genetics of Adverse Drug Reactions - Promises and ProblemsMartin Armstrong Strategies and resources for marker selection and genotyping in geneticassociation studiesNicole Soranzo, Dong-Jing Fu and Qingqin S. Li Study Design and Statistical Methods in Pharmacogenomics Research: FromCandidate Genes to Genome Wide ScreensNicholas J. Schork, Nathalie Malo, Eric J. TopolHoly SNP, Batman!Reyna Favis Use of Predictive Biomarker Classifiers in the Design of Pivotal ClinicalTrialsRichard Simon Translation of biomarkers into clinical utilityWilliam Trepicchio and George Mulligan Pharmacogenomic Study Feasibility Assessment and Pharmaceutical BusinessDecision-MakingMonique Franc and Theresa Frangiosa Co-development of drugs andPharmacogenomics based Diagnostics in Oncology Jeffrey Ross Pharmacogenomics applications in EpilepsyChantal Depondt Pharmacogenomics in Alzheimer's DiseaseRamon Cacabelos Pharmacogenomics applications in Psychiatric disordersTodd Lencz and Anil K. Malhotra Pharmacogenomics in HIV DiseaseAmalio Telenti Pharmacogenomics and Cardiovascular DrugsGérard Siest, Hind Berrahmoune, Jean-Brice Marteau,and Sophie Visvikis-SiestPharmacogenomic applications in ChildrenStruan F.A. Grant and Hakon Hakonarson Pharmacogenomics of rare and monogenic disordersPaul Maher


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