The Melanocortin Receptors

2000
ISBN: 978-0-89603-579-9
Verlag: Humana Press

Buch, Englisch, 542 Seiten, HC runder Rücken kaschiert, Format (B × H): 157 mm x 235 mm, Gewicht: 2190 g

Reihe: The Receptors

Roger Cone and a distinguished team of expert investigators provide the first major treatment of this critically important receptor family. The book illuminates the structure and function of these receptors through a wide-ranging review of the latest findings concerning the biology, physiology, and pharmacology of their peptide ligands and covers the major melanocortin peptides, Melanocortin-1-Receptors through Melanocortin-5-Receptors. Topics include the characterization of the melanocortin receptors, the biochemical mechanism of receptor action, and receptor function and regulation. Timely and authoritative, The Melanocortin Receptors offers an up-to-date knowledge base on the remarkably complex structure and functions of the melanocortins, a guide that will prove invaluable for today's neuroscientists, endocrinologists, pharmacologists, and other clinical and experimental investigators working in this fast moving field.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Cone, Roger D.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Dermatologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Endokrinologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

I. Historical Perspectives.- 1 • Proopiomelanocortin and the Melanocortin Peptides.- 2 • Melanocortins and Pigmentation.- 3 • Melanocortins and Adrenocortical Function.- 4 • Effects of Melanocortins in the Nervous System.- 5 • Peripheral Effects of Melanocortins.- II. Characterization of the Melanocortin Receptors.- 6 • Melanocortin Receptor Expression and Function in the Nervous System.- 7 • Cloning of the Melanocortin Receptors.- III. Biochemical Mechanism of Receptor Action.- 8 • The Molecular Pharmacology of Alpha-Melanocyte Stimulating Hormone: Structure Activity Relationships for Melanotropins at Melanocortin Receptors.- 9 • In Vitro Mutagenesis Studies of Melanocortin Receptor Coupling and Ligand Binding.- IV. Receptor Function.- 10 • The Melanocortin-1 Receptor.- 11 • The Human Melanocortin-1 Receptor.- 12 • The Melanocortin-2 Receptor in Normal Adrenocortical Function and Familial Adrenocorticotropic Hormone Resistance.- 13 • The Melanocortin-3 Receptor.- 14 • The Melanocortin-4 Receptor.- 15 • The Melanocortin-5 Receptor.- V. Receptor Regulation.- 16 • Regulation of the Melanocortin Receptors by Agouti.- 17 • Melanocortins and Melanoma.- 18 • Regulation of the Mouse and Human Melanocortin-1 Receptor.- VI. Future Vistas.- 19 • Future Vistas.