Implantation and Early Development

Erscheinungsjahr 2005
ISBN: 978-1-904752-16-5
Verlag: Royal College of Obstetricians and Gynaecologists (RCOG)

Buch, Englisch, 319 Seiten, Format (B × H): 156 mm x 234 mm, Gewicht: 550 g

Reihe: Royal College of Obstetricians and Gynaecologists Study Group

Successful implantation and early development need a union of healthy genes and an optimal uterine environment. The 48th RCOG Study Group, an international multidisciplinary expert forum, considered factors involved in preparation for implantation within the uterus; how to determine a good egg and good sperm; lessons from animal models; transgenic and genomic technologies; sporadic and recurrent early pregnancy loss; single-embryo transfer; and the developmental consequences of assisted reproduction technologies. This book presents the findings of the Study Group, with sections covering: • preparation for implantation - the uterine environment • the embryo • lessons from animal models (transgenics) and novel technologies • clinical sequelae.

Autoren/Hrsg.

Critchley, Hilary

Cameron, Iain

Smith, Stephen

Inhaltsverzeichnis

Part I. Preparation for Implantation – The Uterine Environment: 1. Endocrine and paracrine signalling in the human endometrium: potential role for the prostanoid family in implantation Henry N. Jabbour, Kurt J. Sales and Hildary O. D. Critchley; 2. Immunology of implantation Anita Trundley, Susan Hiby, Lucy Gardner, Andrew Sharkey, Charlie Loke and Ashley Moffett; 3. Progestin-induced decidualisation promotes human endometrial haemostasis and vascular stability Frederick Schatz, Graciela Krikun, Se-Te Huang, Edmund Funai, Lynn Buchwalder, Mizanur Rahman, Rebeca Caze, Caroline Tang and Charles J. Lockwood; 4. Adhesion molecules and implantation John D. Aplin; 5. Vascular growth and modelling in the endometrium D. Stephen Charnock-Jones; 6. Tissue remodelling at the fetal-maternal interface: the regulation of matrix metalloproteinase 9 transcription Marie Cohen and Paul Bischof; 7. Embryo interactions in human implantation Francisco Domínguez, Jose A. Horcajadas, Ana Cervero, Antonio Pellicer and Carlos Simón; 8. Experimental models of implantation of the human embryo: reconstructing the endometrial-embryo dialogue in vitro Helen Mardon; Part II. The Embryo: 9. What makes a good egg? Alison A. Murray and Norah Spears; 10. What makes 'good sperm'? Allan Pacey; 11. Morphogenesis of the early mammalian embryo: cell lineage heterogeneity and developmental potential Tom P. Fleming, Judith J. Eckert, Fay C. Thomas and Bhavwanti Sheth; 12. Epigenetics in development and cloning by nuclear transfer: alternative approaches to nuclear reprogramming Keith H. S. Campbell and Ramiro Alberio; 13. Risks associated with assisted reproduction: insights from animal studies Kevin D. Sinclair and Ravinder Singh; 14. Pre-implantation genetic testing Peter Braude, Jan Grace and Tarek El Toukhy; Part III. Lessons from Animal Models (Transgenics) and Novel Technologies: 15. To implant or not to implant: the role of leukaemia inhibitory factor Susan J. Kimber, Ali A. Fouladi-Nashta, Lisa Mohamet, Carolyn J. P. Jones and Gemma Schofield; 16. Are gene arrays useful for the study of implantation? Andrew Sharkey, Rob Catalano and Jane Borthwick; Part IV. Clinical Sequelae: 17. Sporadic early pregnancy loss: aetiology and management Siobhan Quenby; 18. Recurrent miscarriage – the role of prothrombotic disorders Arvind Vashisht and Lesley Regan; 19. Reproductive disorders and pregnancy outcome Jan J. Brosens, Luca Fusi, Robert Pijenborg and Ivo A. Brosens; 20. Risk factors for first-trimester miscarriage: summary of results from the National Women's Health Study Noreen Maconochie and Pat Doyle; 21. Single-embryo transfer Siladitya Bhattacharya and Zabeena Pandian; 22. Paediatric outcome after assisted reproductive technology Alastair G Sutcliffe; Part V. Consensus Views: 23. Consensus views arising from the 48th Study Group: Implantation and Early Development; Index.

Über Autor(innen)

Cameron, Iain
Iain Cameron is Professor of Obstetrics and Gynaecology and Dean of the Faculty of Medicine at the University of Southampton.

Smith, Stephen
Stephen Smith is the Vice-President (Research) and Founding Dean of the Lee Kong Chian School of Medicine.

Critchley, Hilary
Hilary Critchley is a Professor at the Royal Infirmary of Edinburgh. She is currently serving on the Academic Committee as Chair of the AAOG.