Current Approaches to Cryo-electron Microscopy

Erscheinungsjahr 2026
ISBN: 978-0-443-43160-9
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 152 mm x 229 mm, Gewicht: 450 g

Current Approaches to Cryo-electron Microscopy, Volume 223 provides a comprehensive overview of the field, tracing its evolution from early structural studies to modern pipelines powered by deep-learning algorithms for helical reconstruction. The book addresses the persistent bottleneck of sample preparation, detailing the physical challenges of fibril clumping and interfacial adsorption, alongside emerging solutions to these problems. Chapters in this new release include Advancing biological understanding of the poxvirus scaffold through breakthroughs in cryo-electron microscopy, Pursuing the physics of cryoEM image formation, AI Tools for Cryo-EM: Protein Particle Picking, Density Map Enhancement, and Atomic Model Building, and much more.

Additional chapters cover Cryo-EM of Amyloid Fibrils: Advances, Challenges, and Translational Applications, Computational Approaches for Protein Complex Modeling for Intermediate Resolution Cryo-EM Maps, Calcium-sensing receptor, involved in the oral perception of the kokumi substances, Insights into the Structure and Diversity of the Bacterial Flagellum from cryo-EM studies, Overview and future potential in structural studies of bacteriophages by cryo-electron microscopy, and more.

Autoren/Hrsg.

Weitere Mitwirkende

Teplow, David B.

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Naturwissenschaften Physik Angewandte Physik Biophysik

Inhaltsverzeichnis

1. Advancing biological understanding of the poxvirus scaffold through breakthroughs in cryo-electron microscopy
Jaekyung Hyun and Seu-Na Lee
2. TBD
Salvador Ventura
3. Pursuing the physics of cryoEM image formation
Duane Loh and Joel Yeo
4. AI Tools for Cryo-EM: Protein Particle Picking, Density Map Enhancement, and Atomic Model Building
Janlin Cheng, Ashwin Dhakal, Rajan Gyawali and Joel Selvaraj
5. Cryo-EM of Amyloid Fibrils: Advances, Challenges, and Translational Applications
Michal Maj and Dylan Valli
6. TBD
Alex de Marco
7. Computational Approaches for Protein Complex Modeling for Intermediate Resolution Cryo-EM Maps
Kihara Daisuke
8. Calcium-sensing receptor, involved in the oral perception of the kokumi substances
Hiroki Yamaguchi and Seiji Kitajima
9. Insights into the Structure and Diversity of the Bacterial Flagellum from cryo-EM studies
Julien Bergeron, Matias R. Iglesias Rando and Kailin Qin
10. TBD
Toshio Moriya
11. TBD
Brent Nannenga
12. Overview and future potential in structural studies of bacteriophages by cryo-electron microscopy
Michael Sherman and Elena Orlova
13. TBA
Seth Darst

Über Autor(innen)

Teplow, David B.
David B. Teplow, Ph.D., is a Professor of Neurology, Emeritus, at UCLA and an internationally recognized leader in efforts to understand and treat Alzheimer's disease. Dr. Teplow's group has used a multi-disciplinary approach to determine how neurotoxic peptides, such as the amyloid ß-protein (Alzheimer's disease) and a-synuclein (Parkinson’s disease), form neurotoxic structures that kill neurons and to develop the means to block these processes. Dr. Teplow received undergraduate training at UC Berkeley; a Ph.D. from the University of Washington; and was a postdoctoral scholar at Caltech. Before coming to UCLA, Dr. Teplow was a faculty member in the Department of Neurology, Harvard Medical School. Dr. Teplow has published >250 peer-reviewed articles, books and book chapters, and commentaries, in addition to serving on numerous national and international scientific advisory boards. Dr. Teplow was a founding editor of the Journal of Molecular Neuroscience and Current Chemical Biology, He is Editor-in-Chief of the Elsevier serial Progress in Molecular Biology and Translational Science and is Associate Editor-in-Chief of the American Journal of Neurodegenerative Disease.