Targeting Functional Centers of the Ribosome

2011
ISBN: 978-3-642-26705-5
Verlag: Springer

Buch, Englisch, 74 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 149 g

Reihe: Springer Theses

This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.

Zielgruppe

Research

Autoren/Hrsg.

Davidovich, Chen

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie Biochemie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Proteinforschung

Inhaltsverzeichnis

Introduction.- Methods.- Results.- Discussion.