Arthropod Vector: Controller of Disease Transmission, Volume 2

Vector Saliva-Host-Pathogen Interactions
Erscheinungsjahr 2017
ISBN: 978-0-12-805360-7
Verlag: Elsevier Science

Buch, Englisch, 332 Seiten, Format (B × H): 188 mm x 234 mm, Gewicht: 680 g

Arthropod Vector: Controller of Disease Transmission, Volume 2: Vector Saliva-Host Pathogen Interactions is built on topics initially raised at a related Keystone Symposium on Arthropod Vectors. Together with the separate, related Volume 1: Controller of Disease Transmission, this work presents a logical sequence of topic development that leads to regulatory considerations for advancing these and related concepts for developing novel control measures.

The three themes of symbionts, vector immune defenses and arthropod saliva modulation of the host environment are central to the concept of determinants of vector competence that involves all aspects of vector-borne pathogen development within the arthropod that culminates in the successful transmission to the vertebrate host.

These three areas are characterized at the present time by rapid achievement of significant, incremental insights, which advances our understanding for a wide variety of arthropod vector species, and this work is the first to extensively integrate these themes.

Autoren/Hrsg.

Dimopoulos, George

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften Evolutionsbiologie
• Naturwissenschaften Biowissenschaften Mikrobiologie
• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Wirbellose (Invertebrata) Insekten (Entomologie)

Inhaltsverzeichnis

1. Network of Cells and Mediators of Innate and Adaptive Cutaneous Immunity: Challenges for an Arthropod Vector
2. Vector Arthropods and Host Pain and Itch Responses
3. Arthropod Modulation of Wound Healing
4. Salivary Kratagonists: Scavengers of Host Physiological Effectors During Blood Feeding
5. Basic and Translational Research on Sand Fly Saliva: Pharmacology, Biomarkers, and Vaccines
6. Unique Features of Vector-Transmitted Leishmaniasis and Their Relevance to Disease Transmission and Control
7. Early Immunological Responses Upon Tsetse Fly–Mediated Trypanosome Inoculation
8. Mosquito Modulation of Arbovirus–Host Interactions
9. Tick Saliva: A Modulator of Host Defenses
10. Tick Saliva and Microbial Effector Molecules: Two Sides of the Same Coin
11. Tsetse Fly Saliva Proteins as Biomarkers of Vector Exposure
12. Epidemiological Applications of Assessing Mosquito Exposure in a Malaria-Endemic Area
13. Ixodes Tick Saliva: A Potent Controller at the Skin Interface of Early Borrelia burgdorferi Sensu Lato Transmission
14. Translation of Saliva Proteins Into Tools to Prevent Vector-Borne Disease Transmission
15. Considerations for the Translation of Vector Biology Research

Über Autor(innen)

Dimopoulos, George
In addition to his academic appointments, Dr. Dimopoulos is Director of the Johns Hopkins Malaria Research Institute Parasitology Core Facility. He is a permanent member of the NIH/NIAID Vector Biology Study Section and has lectured in such areas as Medical Entomology, Vector Biology, Innate Immunity and Molecular Entomology. He has been Editorial Board Member for journals including Insect Physiology and Insect Molecular Biology and has authored or co-authored more than 80 peer-reviewed scientific articles. His group’s research focuses on the mosquito Anopheles gambiae, in such areas as defense mechanisms employed by mosquito vectors against human pathogens, and how naturally occurring microbes of the mosquito intestine can influence the mosquito's susceptibility to infection with human pathogens, with an aim to discover control strategies for vector-borne diseases such as malaria and dengue.