Buch, Englisch, 416 Seiten, Format (B × H): 170 mm x 244 mm
Synthesis and Biomedical Applications
Buch, Englisch, 416 Seiten, Format (B × H): 170 mm x 244 mm
Reihe: Advanced Chemical Products and Materials
ISBN: 978-3-527-35346-0
Verlag: Wiley-VCH GmbH
Fluorescent dye design, synthesis, and biomedical application in one reference
Developing fluorescent dyes with the specificity, sensitivity, and photostability required for biological systems demands integrated knowledge spanning organic synthesis, photophysics, and biomedicine. Fluorescent Dyes: Synthesis and Biomedical Applications consolidates decades of progress into a single reference, covering fluorescence emission principles, rational dye design, and translational applications in sensing, labeling, bioimaging, medical diagnosis, and cancer treatment.
The book details fluorescent chemosensor design for selective recognition of bioactive small molecules in living systems, fluorescence-labeling agents targeting proteins and subcellular organelles, dyes engineered for high-resolution imaging, and theranostic agents combining diagnosis with therapy. Each topic addresses structure-property relationships governing performance under rigorous biological conditions, alongside future development directions for the field.
Readers will also find: - New approaches for rational design of high-performance fluorescent dyes meeting the demanding requirements of in vivo biological applications
- Coverage of photodynamic therapy photosensitizers and their role in targeted cancer treatment strategies using fluorescence-guided approaches
- Analysis of fluorescence phenomena from fundamental photophysical principles through to practical probe construction and deployment in cellular environments
- Discussion of targeted nanodrug delivery systems incorporating fluorescent dyes for combined imaging and therapeutic functionality in living systems
- Evaluation of representative fluorescent dye classes developed over recent decades with detailed synthesis routes and characterization data
Designed for photochemists, cell biologists, pharmaceutical chemists, biochemists, organic chemists, analytical chemists, and sensor industry professionals, this reference provides the design principles, synthetic methods, and application frameworks needed to advance fluorescent dye research from molecular design through clinical translation.
Autoren/Hrsg.
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Weitere Infos & Material
CHAPTER 1 INTRODUCTION
1.1 Overview of the Development of Fluorescence and Phosphorescence
1.2 Mechanisms of Fluorescence and Phosphorescence
References
CHAPTER 2 FLUORESCENT DYES AND THEIR PROSPECTS
2. 1 Common Fluorescent Dyes
2.2 Molecular Design Rules for Near Infrared Fluorescent Dyes
2.3 Future Technology Outlook for Fluorescent Dyes
References
CHAPTER 3 ORGANELLE STAINING FLUORESCENT DYES
3.1 Overview
3.2 Cell Membrane Staining Fluorescent Dyes
3.3 Mitochondrial Staining Fluorescent Dyes
3.4 Lysosomal Staining Fluorescent Dyes
3.5 Golgi Apparatus Staining Fluorescent Dyes
3.6 Endoplasmic Reticulum Staining Fluorescent Dyes
3.7 Nuclear Staining Fluorescent Dyes
References
CHAPTER 4 CELLULAR ENVIRONMENT-SENSITIVE FLUORESCENT DYE
4.1 Polarity-sensitive Fluorescent Dyes
4.2 Temperature Sensitive Fluorescent Dyes
4.3 Viscosity Sensitive Fluorescent Dyes
4.4 pH-sensitive Fluorescent Dyes
4.5 Prospects of Environment-sensitive Fluorescent Dyes in Biomedical Applications
References
CHAPTER 5 FLUORESCENT PROBES FOR INTRACELLULAR ION IMAGING
5.1 Fluorescent Probes for Alkali and Alkaline Earth Metal Ions
5.2 Fluorescent Probe for Normal Transition Metal Ions in Organisms
5.3 Fluorescent Probes for Anions
5.4 Fluorescent Probes for Harmful Heavy Metal Ions
References
CHAPTER 6 FLUORESCENT RECOGNITION DYES FOR THE DETECTION OF BIOACTIVE SMALL MOLECULES
6.1 Introduction
6.2 Fluorescent Recognition Dyes for Reactive Oxygen Species
6.3 Fluorescent Probes for Biological Thiol Compounds Recognition
6.4 Fluorescent Probes for Gasotransmitter Recognition
References
CHAPTER 7 FLUORESCENT RECOGNITION DYE FOR BIOLOGICAL ENZYME
7.1 Introduction
7.2 Fluorescent Probe for Oxidoreductase
7.3 Fluorescent Recognition Dye for Transferase
7.4 Fluorescent Recognition Dye for Hydrolases
References
CHAPTER 8 FLUORESCENT RECOGNITION DYES FOR NUCLEIC ACIDS
8.1 Basic Characteristics of Nucleic Acids
8.2 Basic Principles and Categories of Dyeing
8.3 DNA Fluorescent Dyes
8.4 RNA Fluorescent Dyes
8.5 G tetrad Fluorescent Dyes
8.6 Multifunctional Fluorescent Probes based on Nucleic Acid Staining
References
CHAPTER 9 PROTEIN FLUORESCENT RECOGNITION
9.1 Specific Labeling Techniques
9.2 Small-molecule Ligand
9.3 Peptide Tag Labeling
9.4 Self-labeling Protein Tag
9.5 Aptamer Labeling
9.6 Summary and Outlook
References
CHAPTER 10 THERMALLY ACTIVATED DELAYED FLUORESCENCE DYES
10.1 Introduction
10.2 Structural and Spectral Properties of TADF Dyes
10.3 TADF Dyes for Fluorescence Imaging in Biology
10.4 TADF Dyes for Theranostic Anticancer
10.5 Prospects of Biomedical Applications for TADF Dyes
References
CHAPTER 11 FLUORESCENT DYES FOR SUPER-RESOLUTION IMAGING
11.1 Overview
11.2 Super-Resolution Imaging Technology
11.3 Fluorescent Dyes for Super-Resolution Imaging
11.4 Conclusion and Outlook
References
CHAPTER 12 FLUORESCENT MOLECULAR PRODRUGS
12.1 Fluorescent Molecular Prodrugs Activated by Reductive Biothiols
12.2 Fluorescent Molecular Prodrugs Activated by Hydrogen Peroxide
12.3 Fluorescent Molecular Prodrugs Activated by Enzymes
12.4 Fluorescent Molecular Prodrugs Activated by Acidic pH
12.5 Fluorescent Molecular Prodrugs Activated by External Light
References
CHAPTER 13 PHOTOSENSITIZING DYES FOR LIGHT-TRIGGERED THERAPY
13.1 Overview
13.2 Photosensitizing Dyes for Photodynamic Therapy
13.3 Photosensitizing Dyes for Photothermal Therapy
References
