Glycolysis

Tissue-Specific Metabolic Regulation in Physio-pathological Conditions
Erscheinungsjahr 2023
ISBN: 978-0-323-91704-9
Verlag: Elsevier Inc

Buch, Englisch, 490 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 836 g

Glycolysis: Tissue-Specific Metabolic Regulation in Physio-Pathological Conditions provides an integrated overview of glycolysis, spanning basic biochemistry, patho-physiology and therapeutic applications. The book also instructs in methods available to study the involvement of the glycolytic events in healthy biology and disease pathology. It begins with an overview of fundamental glycobiology followed by chapters dedicated to glycolysis physiology in organs and systems, pathologic conditions related to glycolytic alterations, glycolysis as a therapeutic target and in drug discovery efforts, and methodological approaches to advance new glycolysis research.

Disease areas considered range from cancer to heart failure, diabetes, inborn glycolytic pathway defects, hematologic malignancies, osteoporosis, neurodegenerative diseases and viral Infections. Omics and computational modeling, interactive study methods, and glycolysis flux measurement are described in detail, with step-by-step descriptions of experimental protocols, set-up and analysis.

Zielgruppe

<p>Researchers in Biochemistry, Pharmacology, Medicinal Chemistry, Physiology, Pathology, and Translational Medicine; Students and clinicians</p>

Autoren/Hrsg.

Ferreira, Rita

Oliveira, Pedro Fontes

Nogueira-Ferreira, Rita

Fachgebiete

• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Physik Angewandte Physik Biophysik

Inhaltsverzeichnis

PART I GLYCOLYSIS AND PHYSIOLOGICAL PROCESSES
1. Development and glycolysis dependence
2. Neuro-glia communication and glycolysis
3. Glycolysis and skeletal muscle plasticity
4. Glycolysis and trained heart
5. Bone glycolysis and the regulation of energy balance
6. Glycolysis in adipose tissue-dependent thermogenesis
7. Regulation of glycolysis from a liver-centric perspective

8. Glycolysis as a rheostat mechanism in pancreas function
9. The Warburg-like effect in reproductive events

PART II GLYCOLYSIS AND PATHOLOGICAL EVENTS

10. Exploring glycolytic adaptations in cancer cells
11. The glycolytic pathway to heart failure
12. Glycolysis in PAH and COPD metabolic reprogramming
13. Glycolysis and mitochondrial function in diabetes mellitus

14. Metabolic adaptation to glycolysis as a basic defense mechanism of immune cells
15. Inborn glycolytic pathway defects
16. Enhanced glycolysis and metabolic complications of hematologic malignancies
17. Implications of glycolysis for osteoporosis pathogenesis
18. Glucose, glycolysis, and neurodegenerative diseases
19. Viral Infections and glycolysis

SUPPLEMENTAL INFORMATION – Methodological approaches
20. The application of Omics to explore glycolysis

21. An interactive analysis of glycolysis regulation
22. Measuring glycolysis flux

Über Autor(innen)

Ferreira, Rita
Rita Ferreira has a degree and a PhD in Biochemistry. RF is Assistant Professor at University of Aveiro where she has been teaching courses related to biochemistry and biomedicine to both undergraduate and graduate students. RF develops research work in the field of muscle plasticity in pathophysiological conditions, including the evaluation of the impact of exercise training in cancer-induced muscle wasting using Omics approaches. She is particularly interested in the study of the preventive and therapeutic effect of physical activity in the setting of wasting conditions.

Nogueira-Ferreira, Rita
Rita Nogueira Ferreira has a graduation in Biochemistry (2010), a master's degree in Biochemistry – specialization in Clinical Biochemistry (2012), and a PhD in Biochemistry (2017), obtained at the University of Aveiro (Portugal). She has been developing research work in the study of the molecular and cellular mechanisms associated with different pathological conditions (pulmonary arterial hypertension, heart failure, cancer, obesity) and related to the effect of pharmacological and non-pharmacological approaches (exercise training) in the prevention or treatment of these conditions, using proteomic approaches. Currently, she works as Junior Researcher at UnIC@RISE, Department of Surgery and Physiology from the Faculty of Medicine of the University of Porto, Portugal. She was awarded in the FCT Individual Call to Scientific Employment Stimulus (CEECIND) 2021 to proceed in the study of sexual dimorphism in cardiovascular pathophysiology. In particular, she is interested in exploring the sex differences in heart failure, as well as the adaptations to exercise training, aiming to improve heart failure management.

Oliveira, Pedro Fontes
Pedro Fontes Oliveira, PhD, is an Associate Professor with Habilitation at the University of Aveiro (Portugal) and a Researcher within the LAQV@REQUIMTE (Bio)Chemistry & Omics group. After earning his PhD in Biomedical Sciences from the University of Porto, he established a dedicated research line in reproductive biology and Sertoli cell physiology. Before joining the University of Aveiro, he served as a Principal Researcher at the Institute for Research and Innovation in Health (i3S) and the Faculty of Medicine at the University of Porto. Dr. Oliveira’s research focuses on the molecular control and metabolic modulation of spermatogenesis, specifically investigating how hormonal changes, metabolic behavior, and endocrine disorders impact male fertility. Widely published in the field of male reproductive health, he has co-authored numerous critical texts. He won University of Aveiro 2026 Prize for Pedagogical Innovation.