Insights into Migraine Treatments

Towards Personalized Medicine
Erscheinungsjahr 2025
ISBN: 978-0-443-23649-5
Verlag: Elsevier Science Publishing Co Inc

Buch, Englisch, 316 Seiten, Format (B × H): 191 mm x 234 mm, Gewicht: 654 g

Insights into Migraine Treatments offers a comprehensive overview to guide the selection of the most appropriate therapy for each patient within the landscape of migraine care. It explores the full spectrum of available treatments and their mechanisms of action, while addressing the challenges of individualized therapeutic decision-making. By presenting essential data on efficacy, safety, and biomarkers of treatment response, this book serves as a practical resource for tailoring interventions to patient-specific needs. With its solution-oriented approach, it is a valuable reference for clinicians and researchers striving to advance migraine management.
Covering topics from the clinical characteristics of migraine to acute therapies, pharmacological and nonpharmacological preventive strategies, and clinical, neuroimaging, and neurophysiological biomarkers, this book is designed to meet the complex and evolving needs of migraine patients.

Autoren/Hrsg.

Filippi, Massimo

Messina, Roberta

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften

Inhaltsverzeichnis

1. Clinical manifestations of migraine
2. Why, when, and how to treat migraine patients?
3. Acute treatments: nonsteroidal anti-inflammatory drugs, ergot alkaloids, triptans, and ditans
4. Acute treatments: neuromodulation and peripheral nerve blocks
5. Oral preventive treatments: antidepressants, antihypertensives, anticonvulsants, betablockers, and calcium channel blockers
6. Preventive treatments: onabotulinumtoxinA and peripheral nerve blocks
7. Nonpharmacological approaches in migraine prevention: neuromodulation, nutraceuticals, and behavioral approaches
8. Why target the calcitonin gene-related peptide pathway: Receptors, intracellular pathways, and its role in migraine pathophysiology
9. Gepants
10. Anti-CGRP monoclonal antibodies
11. Biomarkers of treatment response
12. Migraine treatments: what have we learned from neuroimaging?
13. Migraine treatments: what have we learned from neurophysiology?
14. Treatments to use in special circumstances: children, pregnancy, elderly
15. Unmet needs and future perspectives

Über Autor(innen)

Messina, Roberta
Roberta Messina, MD, PhD, is a neurologist with expertise in the evaluation of headache patients, as well as in the analysis of MRI. She is a post-doctoral researcher at the Neuroimaging Research Unit and a headache specialist at the Headache Center at IRCCS Scientific Institute San Raffaele, Milan. Her main interests are studying biomarkers of headache patients´ responses to treatments, and the use of MRI techniques in primary headache disorders. She has applied MRI techniques to study the mechanisms underlying migraine pathophysiology, yielding new insights into brain alterations associated with migraine. She has collaborated in national and international studies assessing the efficacy, safety, and mechanisms of actions of novel treatments employed for migraine prevention. She is the Italian representative in the Juniors Committee of the International Headache Society and part of its Education Committee. She is on the Editorial Board of the Journal of Headache and Pain.

Filippi, Massimo
Massimo Filippi, MD, is Full Professor of Neurology at Vita-Salute San Raffaele University, Director of the Residency School in Neurology, President of the Bacherlor’s Degree in Physiotherapy, Chair of the Neurology and Neurorehabilitation Units, Director of the MS Center, Director of the Neurophysiology Service, and Director of the Neuroimaging Research Unit at IRCCS Scientific Institute San Raffaele, Milan. His research activity has always focused on the definition of the mechanisms underlying various neurological conditions, including multiple sclerosis, neurodegenerative disorders, and migraine. As Director of the of the Neuroimaging Research Unit, he coordinated the MRI acquisition and analysis of several large-scale international MRI-monitored trials of multiple sclerosis. He is member of various national and international Scientific Societies and Boards and for some of them, he holds or has held institutional roles. He is Editor-in-Chief of the Journal of Neurology, Associate Editor of Human Brain Mapping, Radiology, and Neurological Sciences.