Environmental Epigenetics in Toxicology and Public Health

Volume 22
Erscheinungsjahr 2020
ISBN: 978-0-12-819968-8
Verlag: Elsevier Science

Buch, Englisch, 364 Seiten, Format (B × H): 188 mm x 233 mm, Gewicht: 742 g

Environmental Epigenetics in Toxicology and Public Health provides in-depth discussions of the suite of complex environmental factors shown to impact epigenetic components within the cell, as well as evidence that these epigenetic modifications are tied to early and later life health effects. This book offers a translational research perspective, highlighting both in vivo and human population-based evidence for ties between the environment, the epigenome, and health outcomes, with an emphasis on evidence for transgenerational effects of exposures, as well as developmental windows of susceptibility to environmentally-linked epigenetic effects.

This volume in the Translational Epigenetics series aides in the development of new therapeutic options meant to reverse inappropriate epigenetic alterations, helping researchers in their efforts prevent and treat a variety of chronic diseases tied to environmental exposures.

Zielgruppe

<p>Human geneticists; human genomicists; translational researchers in genomic medicine, epigenetics, molecular biology, toxicology, public health, environmental science; life science researchers; oncologists; immunologists; bioengineers; developmental biologists</p>

Autoren/Hrsg.

Fry, Rebecca

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Public Health, Gesundheitsmanagement, Gesundheitsökonomie, Gesundheitspolitik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Umweltmedizin, Arbeitsmedizin, Tropenmedizin, Sportmedizin Umweltmedizin

Inhaltsverzeichnis

Section I. Epigenetic Mechanisms/Machinery
1. DNA methylation/chromatic regulation/non-coding RNAs
2. Tools for the assessment of epigenetic regulation

Section II. Transdisciplinary approaches for the study of environmental epigenetics

3. Model organisms and their application in environmental epigenetics
4. Epidemiological concepts in environmental epigenetics

Section III. Epigenetic programming of disease in relation to the environment
5. Pregnancy and Birth outcomes
6. Neurodevelopment outcomes
7. Cancer
8. Respiratory dysfunction
9. Immune dysfunction
10. Cardio/Metabolic disease
11. Aging

Section IV. Transgenerational epigenetic effects of the environment
12. Transgenerational effects of environmental contaminants

Section V. Epigenome-targeted therapies in environmental health science
13. Nutrition
14. Manipulation of Epigenetic machinery

Section VI. Conclusions and Future Perspectives

15. Conclusions and Future Perspectives: The environment and the epigenome

Über Autor(innen)

Fry, Rebecca
Dr. Fry is Director of the Institute for Environmental Health Solutions and the Carol Remmer Angle Distinguished Professor in the Department of Environmental Sciences and Engineering at UNC-Chapel Hill. Her lab focuses on understanding how environmental exposures to toxic substances are associated with human disease. With a particular focus on genomic and epigenomic perturbations, her lab uses toxicogenomic and systems biology approaches to identify key molecular pathways that associate environmental exposure with diseases. A current focus in the lab is to study prenatal exposure to various environmental contaminants including arsenic, cadmium, and perflourinated chemicals. Dr. Fry aims to understand molecular mechanisms by which such early exposures are associated with long-term health effects in humans. Ultimately, Dr. Fry’s lab aims to identify mechanisms of contaminant-induced disease and the basis for inter-individual disease susceptibility.