Functional Neural Transplantation IV

Translation to Clinical Application, Part B
Erscheinungsjahr 2017
ISBN: 978-0-12-813879-3
Verlag: William Andrew Publishing

Buch, Englisch, 316 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 810 g

Functional Neural Transplantation IV: Translation to Clinical Application, Part B, Volume 231 provides the current status of cell transplantation in the nervous system, focusing on the conditions for achieving structural repair and functional recovery. New to this edition are chapters on Plasticity and Regeneration in the Injured Spinal Cord After Cell Transplantation Therapy, Transplantation of GABAergic Interneurons for Cell-Based Therapy, Rebuilding CNS Inhibitory Circuits to Control Chronic Neuropathic Pain and Itch, From Transplanting Schwann Cells in Experimental Rat Spinal Cord Injury to their Transplantation into Human Injured Spinal Cord in Clinical Trials, and the Recruitment of Endogenous CNS Stem Cells for Regeneration in Demyelinating Disease.

As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments in cellular and molecular science, providing the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, while also addressing the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair.

Autoren/Hrsg.

Weitere Mitwirkende

Dunnett, Stephen B.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Chirurgie Transplantationschirurgie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Chirurgie Neurochirurgie

Inhaltsverzeichnis

1. Stem Cell Transplantation for Spinal Cord Injury Repair
Paul Lu
2. Plasticity and Regeneration in the Injured Spinal Cord After Cell Transplantation Therapy

Satoshi Nori, Masaya Nakamura and Hideyuki Okano
3. Transplantation of GABAergic Interneurons for Cell-Based Therapy
Julien Spatazza, Walter R. Mancia Leon and Arturo Alvarez-Buylla
4. Rebuilding CNS Inhibitory Circuits to Control Chronic Neuropathic Pain and Itch
Joao M. Braz, Alex Etlin, Dina Juarez-Salinas, Ida J. Llewellyn-Smith and Allan I. Basbaum
5. From Transplanting Schwann Cells in Experimental Rat Spinal Cord Injury to their Transplantation into Human Injured Spinal Cord in Clinical Trials
Mary B. Bunge, Paula V. Monje, Aisha Khan and Patrick M. Wood
6. Recruitment of Endogenous CNS Stem Cells for Regeneration in Demyelinating Disease
Natalia A. Murphy and Robin J.M. Franklin
7. Progenitor Cell-Based Treatment of Glial Disease
Steven A. Goldman
8. Pluripotent Stem Cells and their Utility in Treating Photoreceptor Degenerations
Nozie D. Aghaizu, Kamil Kruczek, Anai Gonzalez-Cordero, Robin R. Ali and Rachael A. Pearson
9. Stem Cell-Derived Retinal Pigment Epithelium Transplantation for Treatment of Retinal Disease
Britta Nommiste, Kate Fynes, Victoria E. Tovell, Conor Ramsden, Lyndon da Cruz and Peter Coffey
10. Transplantation of Reprogrammed Neurons for Improved Recovery After Stroke
Zaal Kokaia, Daniel Tornero and Olle Lindvall

Über Autor(innen)

Dunnett, Stephen B.
Dunnett is a behavioural neuroscientist who started a lifelong collaboration with the Björklund team in 1979 to explore the functional consequences of cell transplantation method in animal models of neurodegenerative disease, in particular involving cell replacement and repair of the basal ganglia. He has developed models and novel methods of motor and cognitive assessment to apply behavioural analysis not simply to assess functional efficacy of implanted cells, but as a tool to study the mechanisms of cell integration, circuit reconstruction and functional repair. In parallel his laboratory originated the first UK trial of cell transplantation in Huntington’s disease, and provides the source of clinical grade cells for further ongoing trials in Parkinson’s disease.