Development of Therapeutic Agents Handbook

1. Auflage 2011
ISBN: 978-0-471-21385-7
Verlag: Turner Publishing Company

Buch, Englisch, 1280 Seiten, Format (B × H): 228 mm x 292 mm, Gewicht: 2855 g

Reihe: Pharmaceutical Development

This book is a one-stop compendium of up-to-date concepts, approaches, methodologies, and limitations in drug development and therapeutics. It provides researchers with a thorough reference focusing on applications, practical methods, and techniques to facilitate new drug development. Taking an in-depth look into novel treatments and therapeutics, the text includes chapters on hot topics like new drugs and neutraceuticals, the discovery and development of vaccines, cancer therapeutics, and market overviews. The coverage also presents chapters on therapeutic drug development for specific disease areas: cardiology, oncology, breast cancer, kidney diseases, and so on.

Autoren/Hrsg.

Gad, Shayne Cox

Fachgebiete

• Wirtschaftswissenschaften Wirtschaftssektoren & Branchen Fertigungsindustrie Pharmaindustrie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie

Inhaltsverzeichnis

PREFACE ix

CONTRIBUTORS xi

PART I FUNDAMENTAL CONCEPTS 1

1. Current Needs for New Therapeutic Agents and Discovery Strategies--A Systems Pharmacology Approach 3
Sophie C. Desbiens and David H. Farb

2. Target Selection in Drug Discovery 25
Charles F. Albright

3. New Drug Applications 35
John S. McInnes and Donald O. Beers

4. From Concept to the Clinics: Development of Cancer Therapeutics 47
Balveen Kaur, Gregory B. Lesinski, and Abhik Ray Chaudhary

5. Development of Countermeasures for Bioterrorism in the United States 73
Gregory H. Levine and Jeffrey I. Handwerker

6. Development and Application of Conformation-Selective Integrin Antibodies 91
Nathan S. Astrof, Dan Peer, and Motomu Shimaoka

7. Pain Management Market Overview 113
Anita Holdcroft

8. Antiviral Market Overview 127
Anita Arora, Natalia Mendoza, and Stephen K. Tyring

PART II METHODS AND TECHNIQUES IN DRUG DISCOVERY AND DEVELOPMENT 145

9. High-Throughput Screening for Small-Molecule Drug Discovery 147
C. Parker and J.-H. Zhang

10. Mass Spectrometry 181
Robert D. English and Anthony M. Haag

11. Molecular Screening for Therapeutic Agents 207
R. Damoiseaux

12. Accelerator Mass Spectrometry and Positron Emission Tomography in Human Microdosing 241
Zhengdong Cheng

13. Development of Antimicrobial Peptides as Therapeutic Agents 285
Robert S. Hodges, Ziqing Jiang, James Whitehurst, and Colin T. Mant

14. Antibodies for Human Diseases 359
Guo-Liang Yu and Jian Ni

15. Combinatorial Compounds and Drug Discovery 399
James C. Bigelow

16. Locoregional Chemoradiotherapy of Cancer Using Hydrogel 413
David J. Yang, Ali Azhdarinia, Hiroaki Kurihara, and E. Edmund Kim

17. RNAi-Mediated Therapeutics 425
Nuria Morral and Scott R. Witting

18. Crystallography 445
Carl H. Schwalbe

19. PEGylation 463
Sanju Dhawan, Deepak N. Kapoor, Rishi Kapil, Mano Kumarj, and Ankur Bansal

20. Gold Standard Animal Models 517
Carol Casteneda and Michael S. LaPointe

21. Discovery of Vaccine Adjuvants 533
Fiona A. Sharp and Ed C. Lavelle

22. Oral Delivery of Macromolecules for the Development of Therapeutic Agents 547
Hye J. Lee and Chanmi Choi

23. Aerosol Drug Delivery to the Lungs 565
Andrew R. Martin and Warren H. Finlay

24. Resistance to Antiplatelet Theraphy 589
Paul A. Gurbel, Udaya S. Tantry, and Mark J. Antonino

25. Antibiotic Development 611
Robert L. Bettiker and Jason C. Gallagher

PART III THERAPEUTIC TOPICS 629

26. Antimicrobial Resistance in Biofi lms: A Sticky Situation 631
Shu Yeong Queck and Michael Otto

27. Drotrecogin Alfa Activated (Recombinant Human Activated Protein C, Xigris) 645
Byungse Suh and Rafi k Samuel

28. Anti-Inflammatory Therapeutics 655
Marion M. Chan and Dunne Fong

29. Anti-Inflammatory/Analgesics: An In-depth Look at p38 MAP Kinases 673
Kelly L. Brown

30. Cardiovascular Disease: In-Depth Look 707
Nicholas B. Norgard and Mazen Abu-Fadel

31. Ezetimibe and Cholesterol Absorption 723
Stefan Oswald and Werner Siegmund

32. Cardiology--In-Depth Look: Kinases as Therapeutic Targets in the Heart 743
Karin Mauer and J. Emilio Exaire

33. Statins in the Reduction of Cardiovascular Events 773
Rajesh Sachdeva, Bradley Hughes, and Jawahar L. Mehta

34. Cardiology--In-Depth Look: Advances in Antiplatelet Theraphy 785
Karin Mauer and Jorge F. Saucedo

35. Gastrointestinal Disorders: A Focus on Acid-Suppressive Agents 813
Brian Hemstreet

36. Pharmacology of Vasopressin and the Renin--Angiotension--Aldosterone System 825
Elizabeth J. Brant and Julian L. Seifter

37. New Drugs and Nutaceutical in the Treatment of Osteoarthristis 847
Y. Henrotin and J. Y. Reginster

38. Development of Anticytokine Agents for Rheumatoid Arthritis 881
Jonathan Sherlock, Christopher D. Buckley, and Karim Raza

39. Overview of CNS Neuropharmaceuticals 897
Tauser Roxana-Georgiana and Antohe Dan-Stefan

40. Thinking Outside the Box in Alzheimer Disease Treat

Über Autor(innen)

Gad, Shayne Cox
SHAYNE COX GAD, PhD, DABT, ATS, is the Principal of Gad Consulting Services. He has more than thirty years of experience as a toxicologist, statistical consultant, manager, and consultant on research and development in the chemical, consumer product, contract testing, biotechnology, medical device, and pharmaceutical industries. He is the author of forty-two books and numerous papers, presentations, and other publications

SHAYNE COX GAD, PhD, DABT, ATS, is the Principal of Gad Consulting Services. He has more than thirty years of experience as a toxicologist, statistical consultant, manager, and consultant on research and development in the chemical, consumer product, contract testing, biotechnology, medical device, and pharmaceutical industries. He is the author of forty-two books and numerous papers, presentations, and other publications.