Buch, Englisch, 420 Seiten, Format (B × H): 242 mm x 164 mm, Gewicht: 764 g
Formulations, Routes and Regimens for Solving Drug Delivery Problems in Animal Model Systems
Buch, Englisch, 420 Seiten, Format (B × H): 242 mm x 164 mm, Gewicht: 764 g
ISBN: 978-1-4665-0253-6
Verlag: Taylor & Francis Inc
The trio of objectives this book explores are: first, to present how to deliver more of a drug product systemically to facilitate the regulatory need for evaluating safety and efficacy in animal species (at elevated exposure levels) prior to advancing the drug to human testing; second is to achieve better tolerance to therapeutics administration in test animals and humans which achieves objectives 1 and 3; and third, to explore ways to improve on therapeutic target receptor delivery performance, therefore improving both clinical pharmacodynamics bioavailability and specificity.
The book’s ten chapters assemble the basic concepts, principles and hypotheses involved in quantitative receptor and chronological organism interaction dynamics central to the successful development of new therapeutics which depend on systemic administration to achieve desired therapeutic goals and in so doing avoid outcomes which limit, marginalize, or preclude the therapeutic use of so many molecules.
Zielgruppe
Professional Reference
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
Preface, About the Author, Chapter 1: Introduction, Chapter 2: Pharmacotherapy, Toxicodynamics, and Regulatory Science – Divergent Objectives, Chapter 3: Nonclinical Pharmacokinetics and Toxicokinetics – A Primer, Chapter 4: Routes of Administration: With Considerations for Species Specificity, Chapter 5: Delivery Systems, Chapter 6: Dosing Regimens as a Means of Improving Drug Delivery and Tolerance, Chapter 7: The Utility of Circadian Oscillations in Formulation and Drug Development, Chapter 8: Fundamentals of Nonclinical Formulation: Chemistry and Biological Behavior, Chapter 9: Vehicles and Excipients, Chapter 10: Practical Ways of Improving Regional and Selective Drug Delivery, Appendix: Vehicles and Excipients, Index