Multiple Myeloma and Related Disorders

1. Auflage 2004
ISBN: 978-0-340-81010-1
Verlag: Taylor & Francis Ltd

Buch, Englisch, 488 Seiten, Format (B × H): 210 mm x 279 mm, Gewicht: 1442 g

During the past decade there has been an enormous increase in knowledge of multiple myeloma and related disorders, reflected in the publication of more than 5000 articles on the subject in scientific journals. Much of this has come about as new technologies have made it possible to refine studies on chromosomes and genes and to gain information about gene expression.

It is therefore highly appropriate that this new comprehensive reference should appear at this time. The book covers the whole field of multiple myeloma, and also related diseases such as Waldemström’s macroglobulinaemia, and incorporates both the basic science underlying the diseases and their clinical management. Each chapter has been written to ’stand alone’, allowing the reader to dip into a particular subject and find information quickly without the need to browse through multiple chapters. In addition to the developments described above, all of which are considered here, many other approaches to targeted therapy are reviewed.

Zielgruppe

Professional Reference

Autoren/Hrsg.

Gahrton, Gosta

Durie, Brian

Samson, Diana

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Hämatologie, Transfusionsmedizin

Inhaltsverzeichnis

Part 1. History of multiple myeloma Epidemiology and etiology of plasma cell neoplasms

Part 2. The immune system in myeloma Molecular biology and cytogenetics Biology of the malignant plasma cell Pathophysiology of myeloma bone disease

Part 3. Clinical features Hematologic investigations: Morphologic and phenotypic

Part 4. Biochemical and immunological investigations The role of imaging in multiple myeloma Innovative approaches for diagnosis and monitoring Differential diagnosis and prognosis

Part 5. Principles of management Chemotherapy, steroids and interferon Radiotherapy Autologous stem cell transplantation Allogeneic transplantation and treatment with donor lymphocytes Supportive care Biological basis of therapy: New molecular targets Immunotherapeutic approaches

Part 6. Management of bone disease Management of myeloma patients with renal failure Neurologic aspects of monoclonal gammopathy of undetermined significance, multiple myeloma, and related disorders

Part 7. Monoclonal gammopathies of undetermined significance: the transition from MGUS to myeloma Solitary bone and extramedullary plasmacytoma Plasma cell leukaemia AL amyloidosis Heavy-chain diseases Waldenström’s disease

Über Autor(innen)

Gösta Gahrton MD PhD
Professor, Department of Medicine, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden

Brian G.M. Durie MD
Attending Physician, Department of Hematology and Oncology, Cedars-Sinai Comprehensive Cancer Centre, Los Angeles, CA, USA

Diana M. Samson MD
Senior Lecturer in Haematology, Hammersmith Hospital, London, UK