Buch, Englisch, 526 Seiten, Format (B × H): 214 mm x 274 mm, Gewicht: 1383 g
From Many, One
Buch, Englisch, 526 Seiten, Format (B × H): 214 mm x 274 mm, Gewicht: 1383 g
ISBN: 978-0-12-822546-2
Verlag: Elsevier Science
The Vasculome: From Many, One introduces the fundamental bases of the "unity in diversity� of the Vasculome, from the coming together of various cell lineages during development, to its deceptively simple solution for architectural design: the efficient interplay of a few types of building blocks supporting key similar functions throughout the body and their highly specialized functional local variations. Specific examples are included to illustrate how the Vasculome is integral to the function and malfunction of different organs, such as the brain or the kidney.
Each section is preceded by an introductory summary that will give a high level unified view of the key concepts illustrated in the various chapters in that section.
Zorina Galis' The Vasculome was named a finalist in the Clinical Medicine category of the American Association of Publishers' 2023 PROSE Awards.
Zielgruppe
basic and clinical researchers within various areas of Vascular Biology, Medicine and Cardiology; as well as researchers who need to understand the vasculome concept such as in fields of neuroscience, genetics, physiology, or pharmacology
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
PART I. THE ARCHITECTURAL DESIGN OF THE VASCULOME: BASIS FOR SYSTEM-WIDE FUNCTIONAL UNITY AND LOCAL DIVERSITY
SECTION 1. The Endothelium: Key Unifying Principle of the Vasculome. Basis for Systemic Unity and for Engineering of Local Specialization
1. Developmental of, and environmental impact on, endothelial cell diversity
2. Endothelial cell heterogeneity in health and disease – new insights from single cell studies
SECTION 2. Vasculome’s Key Building Blocks - Beyond the Endothelium
3. The Remarkable Diversity of Vascular Smooth Muscle in Development and Disease: A paradigm for mesenchymal cell types
4. SMC contractile diversity
5. Resident vascular immune cells in health and atherosclerotic disease
6. Perivascular adipose tissue (physiology, pathology)
7. Major vascular ECM components, differential distribution supporting structure and functions of the Vasculome
SECTION 3. Putting it all Together: Integration across Body Scales and within Tissues
8. Out to the Tissues: The Arterial Side (Arteries, Arterioles - Development, Structure, Functions, Pathologies)
9. Capillary diversity: endothelial cell specializations to meet tissue metabolic needs
10. The neurovascular unit and blood-CNS barriers in health and disease
11. Lymphatic biology and medicine
PART II. INVESTIGATING THE VASCULOME: CONTEXT-DRIVEN METHODS, USES AND LIMITATIONS
SECTION 1. Experimental and Computational Studies of the Vasculome
12. The Flow-dependent Endotheliome: Hemodynamic Forces, Genetic Programs, and Functional Phenotypes
13. Intravital photoacoustic microscopy of microvascular function and oxygen metabolism’
14. Systems biology modeling of endothelial cell and macrophage signaling in angiogenesis in human diseases
15. Simulation of blood flow and oxygen transport in vascular networks
16. Clinical Investigations of vascular function
SECTION 2. Realizing the Promise of New High Content Technologies
17. Angiodiversity – A tale retold by compara
