Synthetic Polymerization in Living Systems

Design, Preparation, and Applications
1. Auflage 2027
ISBN: 978-3-527-35357-6
Verlag: Wiley-VCH GmbH

Buch, Englisch, 224 Seiten, Format (B × H): 170 mm x 244 mm

Connecting natural and synthetic polymerization processes within living systems

Conducting synthetic polymerization inside living systems opens direct routes to novel therapeutics and biotechnologies. Synthetic Polymerization in Living Systems: Design, Preparation, and Applications presents current research on designing, preparing, and deploying synthetic polymers within biological environments. The volume systematically compares natural and synthetic polymerization, establishing the rationale for engineering polymer formation in situ rather than relying on ex vivo synthesis.

Chapters address molecular design principles governing monomer selection, polymerization techniques adapted for intracellular and in vivo conditions, and critical parameters of biocompatibility and biodegradability. The book examines downstream applications in biotechnology, nanotechnology, and therapeutics, detailing how synthetic polymers interact with cellular machinery. It concludes by assessing key findings and outlining future research directions for this field.

Readers will also find: - Analysis of challenges specific to initiating and controlling polymerization reactions under the constraints of living biological environments
- Discussion of supramolecular self-assembly strategies that enable functional polymer architectures to form within cellular compartments
- Coverage of intracellular polymerization approaches with direct relevance to emerging cancer treatment modalities and targeted drug delivery
- Examination of biodegradable polymer design criteria that balance therapeutic efficacy with safe clearance from biological systems
- Perspectives on integrating synthetic polymerization with tissue engineering, biomedical device fabrication, and regenerative medicine applications

Polymer chemists, cell biologists, materials scientists, medicinal chemists, biochemists, and biotechnologists in both academia and industry will find this volume a focused resource for understanding and advancing synthetic polymerization within living systems and translating these processes into biomedical and technological applications.

Autoren/Hrsg.

Geng, Jin

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Technologie der Kunststoffe und Polymere
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

1 INTRODUCTION
1.1 Motivation for Synthesizing New Polymers Inside Living Systems
1.2 Comparison of Natural and Synthetic Polymers in Living Systems
1.3 Overview of the Scope and Content of the Book
 
2 POLYMERIZATION TECHNIQUES INSIDE LIVING SYSTEMS
2.1 Overview of polymerization techniques inside living systems
2.2 Comparison of the advantages and disadvantages of different techniques
2.3 Details on the polymerization of various monomers including acrylates, methacrylates, vinyl monomers, and others
2.4 Discussion on the use of bioorthogonal reactions for synthetic polymerization
 
3 DESIGN AND PREPARATION OF POLYMERS INSIDE LIVING SYSTEMS
3.1 Molecular design principles for synthetic polymers inside living systems
3.2 Supramolecular polymerization in living systems
 
4 APPLICATIONS OF SYNTHETIC POLYMERS INSIDE LIVING SYSTEMS
4.1 Polymerization in living system for bacteria infected Wound healing and monitoring
4.2 In Vivo Polymerization for preparing Bio-electronics device
4.3 Polymerization in living system for applications in Tissue Engineering
4.4 Polymerization in Living system for therapeutic applications
4.5 Polymerization in Living system for Bacterial Growth Inhibition, Selective binding and labelling, surface electric property Modification, Bacterial encapsulation and differentiation
 
5 BIOCOMPATIBILITY AND BIODEGRADABILITY OF SYNTHETIC POLYMERS INSIDE LIVING SYSTEMS
5.1 Biocompatibility polymerization components
5.2 Biocompatibility of polymerization reaction process
5.3 Precise spatiotemporal control for biocompatibility
5.4 Biological properties improvement of living systems after polymerization
5.5 Immunotoxicity from formed polymers
 
6 EMERGING TRENDS AND INNOVATIONS IN SYNTHETIC POLYMERIZATION
6.1 Sustainable and Green Polymerization
6.2 Advanced Functional Polymers
6.3 Advanced Polymer Processing Techniques
 
7 CONCLUSION
7.1 Synthesis of Core Concepts Across the Book
7.2 Conceptual Advances Enabled by In Situ Polymerization
7.3 Implications for Biomedical Technologies and Therapies
7.4 Challenges That Must Be Addressed
7.5 Future Outlook: Toward Integrated and Intelligent Polymer Systems
7.6 Concluding Remarks

Über Autor(innen)

Jin Geng is Principal Investigator and Director of the Centre for Polymers in Medicine at the Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences. A Fellow of the Royal Society of Chemistry, his research focuses on intracellular polymerization for cancer treatment and supramolecular self-assembly in living cells. He previously conducted postdoctoral research at the University of Cambridge and University of Edinburgh. He holds some 40 published papers and 10 filed patents, and has received the Conference Prize from the Chinese Chemical Society and the High-Value Patent Prize from the Chinese Society of Biomedical Engineering.